Immunohistochemical analysis of anaplastic lymphoma kinase expression in deep soft tissue calcifying fibrous pseudotumor: Evidence of a late sclerosing stage of inflammatory myofibroblastic tumor?

Large retroperitoneal calcifying fibrous tumor

“…A few were thought to evolve from inflammatory myofibroblastic tumor (IMT), but larger studies failed to confirm this and ultra structural studies revealed fibroblastic features. 4,5 A genetic susceptibility theory was also floated but has not been substantiated. 6 These lesions were originally described as arising in the subcutaneous and deep soft tissues, mostly in the extremities and the neck areas 3 but more recently CFT have been found to be ubiquitous.…”

“…However, these tumors show a different immunohistochemical profile and a different biological behavior. 5,6 Retroperitoneal fibrosis can also be considered as a differential diagnosis for the tumor in retroperitoneal location specially when associated with other fibrosing conditions, such as inflammatory pseudotumor or retractile mesenteritis. But in these lesions, there are no psammomatous calcifications, as seen in our case.…”

Calcifying Fibrous Pseudotumor versus Inflammatory Myofibroblastic Tumor: A Histological and Immunohistochemical Comparison

“…It is interesting that anaplastic lymphoma kinase oncogenes have been found recently in inflammatory myofibroblastic tumor (33). Unlike IMTs, CFPs in deep soft tissue locations have been reported negative for anaplastic lymphoma kinase (34), suggesting that CFP is a different clinicopathologic entity than IMT.…”

Calcifying Fibrous Tumor of the Gastrointestinal Tract

“…The most commonly involved sites are the stomach [3][4][5][6][7][8][9][10][11][12][13][14][15][16] and small intestine. 3,4,6,14,[17][18][19][20][21][22][23][24][25] Three examples in the large intestine exist 14,17,26 and a single case in the esophagus. 27 Patient age ranges from 5 to 77 years, with a mean of 40.8 years; no sex predilection is evident.…”