Immunohistochemical analyses of CD44 variant isoforms in invasive micropapillary carcinoma of the breast: comparison with a concurrent conventional invasive carcinoma of no special type component

Umeda, Tomoko; Ishida, Mitsuaki; Murata, Satoshi; Mori, Taisuke; Kawai, Yosuke; Itoi, Naoko; Tomida, Kaori; Tanaka, Atsunori; Sakai, Sachiko; Kitamura, Mina; Kubota, Yoshihiro; Kushima, Ryoji; Tani, Masaji

doi:10.1007/s12282-015-0653-4

Cited by 19 publications

(22 citation statements)

References 24 publications

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“…This was a higher frequency than that reported by others (about 2%) [11][12][13]. Despite our small number of cases (n=29), the 3-year and subsequent cumulative disease-free survival rates plateaued at 58.8%, and the 6-year and subsequent cumulative survival rates plateaued at 60.8%.…”

Section: Discussioncontrasting

confidence: 57%

Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases

Kinoshita¹,

Fukushima²,

Miyake³

et al. 2015

Breast Can Curr Res

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Section: Discussioncontrasting

confidence: 57%

Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases

Kinoshita¹,

Fukushima²,

Miyake³

et al. 2015

Breast Can Curr Res

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“…[ 15 ] In contrast, it can express in a variety of breast cancer. [ 15 – 17 ] However, this had no reports of the CD44v expression in myoepithelial and squamous differentiation of LGASC previously. Furthermore, CD44v, a widely accepted cancer stem cell (CSC) marker in breast cancer, is considered to promote the tumor progression in various cancers.…”

Section: Discussionmentioning

confidence: 98%

Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast

Wu¹,

Zhang²,

Wang

et al. 2017

Medicine

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Rationale:Low-grade adenosquamous carcinoma (LGASC) is a rare subtype of metaplastic breast carcinoma which is generally recognized as a characteristic subgroup of triple-negative breast cancers previously. However, in this study, we reported for the first time a case of LGASC with hormone receptors expression.Patient concerns:Pathological analysis of breast tumor specimen obtained by a 42-year-old female patient was performed. Morphologically, it composed of glandular structures with scattered squamous differentiation accompanied by haphazard arrangement of spindle cell stroma. Immunohistochemically, all myoepithelial and squamous differentiation markers showed typical LGASC positive or negative staining pattern. Interestingly, we found that normally aberrant hormone receptors were reactivated in this case. To our knowledge, this is the first report of a hormone receptor-positive LGASC. Apart from this, in the extended resection sample, we found scattered squamous metaplasia and florid adenosquamous proliferation (ASP). Meanwhile, it was positive for CD44 variant isoforms (CD44v), which is a breast cancer stem cell (CSC) marker, and expressed in LGASC, squamous metaplasia, and ASP.Diagnosis:LGASC with hormone receptors expression.Interventions:The breast-extended local excision and axillary lymph node dissection were performed.Outcomes:The patient was free of local recurrence and distant metastasis 6 months after surgical resection.Lessons:We herein report the first case of LGASC with immunoreactivity for hormone receptors, expanding its profile of immunophenotypes. CD44v may play an important role in the transition of LGASC precursor lesions into malignant processes, which may serve as a therapeutic target in LGASC.

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“…55 Li et al 51 demonstrated that the ratio of CD44 þ to CD24 À/low tumor cells was higher in IMPCs than it was in IDC-NOS, and the increased CD44 þ to CD24 À/low ratio was associated with more-frequent metastasis of IMPC and a worse prognosis. Umeda et al 56 reported that downregulation of CD44v6, a CD44 variant isoform, was specifically associated with LNM of IMPCs. Interestingly, Badyal et al 37 reported 7 cases of IMPC that regained CD44 expression at the LNM site and hypothesized that its reexpression at the metastatic site had a role in the homing of tumor cells.…”

Section: Mechanism Of Metastasismentioning

confidence: 99%

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

107

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Context.-Invasive micropapillary carcinoma (IMPC) is a distinct variant of mammary carcinoma in which tumor cells are arranged in morulelike clusters devoid of fibrovascular cores and situated within empty stromal spaces. Identification of IMPC can be achieved by the assessment of morphologic features in conjunction with the characteristic ''inside-out'' staining pattern of epithelial membrane antigen and sialyl Lewis X highlighted by immunohistochemical analysis. Although recognizing micropapillary architecture is often not challenging, the criteria for distinguishing between mixed and pure IMPC remain imprecise. Some mucin-producing carcinomas can also have micropapillary histology, but there is no consensus on whether these tumors are variants of IMPC or mucinous carcinomas. The molecular genetic studies demonstrate that IMPCs have distinct molecular genetic profiles, supporting the theory that they constitute distinct pathologic entities. However, genomic analyses have not identified any specific genomic aberration that may explain the distinctive morphology and clinical behavior of IMPC.Objective.-To provide an overview on the current concepts in the diagnosis and pathogenesis of IMPC of the breast, incorporating recent molecular genetic advances and prognosis-based reclassification.Data Sources.-PubMed search and the cited references were reviewed.Conclusions.-The recent evolution of prognosis-based reclassification and molecular genetic advances has enhanced our knowledge of the pathogenesis of IMPC of the breast. Additional studies might reveal consistent molecular alterations that underlie the formation of the inside-out growth pattern, and they might elucidate the molecular mechanisms responsible for the unfavorable clinical behavior of IMPC.

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Immunohistochemical analyses of CD44 variant isoforms in invasive micropapillary carcinoma of the breast: comparison with a concurrent conventional invasive carcinoma of no special type component

Cited by 19 publications

References 24 publications

Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases

Clinicopathological Assessment of Patients with Locally Advanced Breast Cancer with 10 or More Lymph Node Metastases

Expression of hormone receptors in low-grade adenosquamous carcinoma of the breast

Invasive Micropapillary Carcinoma of the Breast: An Update

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