Immunohematopoietic modulation by oral β-1,3-glucan in mice infected with Listeria monocytogenes

Torello, Cristiane Okuda; Queiroz, Julia de Souza; Oliveira, Sueli C.; Queiroz, Mary L.S.

doi:10.1016/j.intimp.2010.09.009

Cited by 17 publications

(11 citation statements)

References 49 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18,[40][41][42] Moreover, IFN-g has been reported to augment the expression of M-CSF, M-CSFR, and GM-CSFR in bone marrow stroma and thus support the myelopoiesis during infections. 25,38,40,42 In conclusion, the finding of the present study demonstrate for the first time that Listeria exposure of tumor-bearing host is associated with an upregulated differentiation of macrophages from precursor BMC accompanied by polarization of the phenotype of TAM to a proinflammtory subtype, possibly an intermediate between M1 and M2 subtypes with augmented tumoricidal action. The results of the study will help in exploiting beneficial aspects of host-microbe relationship for survival benefits in tumor-bearing hosts.…”

Section: Discussionsupporting

confidence: 59%

“…9,37,38 Considering the previous reports where augmented tumor infiltration of macrophages has been correlated to an elevated myelopoietic differentiation of BMC, 10,39 we next checked if Listeria infection could alter the process of differentiation of macrophages from precursor BMC in a tumor-bearing host. Indeed, the results of the present study demonstrate an augmented bone marrow cellularity, improved BMC survival accompanied by an inhibition of proapoptotic PUMA expression, and enhanced macrophage colony-forming ability.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Augmented Macrophage Differentiation and Polarization of Tumor-associated Macrophages Towards M1 Subtype in Listeria-administered Tumor-bearing Host

Rakesh

Vishvakarma

Mohapatra

et al. 2012

Journal of Immunotherapy

View full text Add to dashboard Cite

This study investigates the effect of Listeria administration on differentiation of macrophages from precursor bone marrow cells and functional status of tumor-associated macrophages (TAM). Listeria administration not only resulted in an augmented infiltration of tumor by F4/80 macrophages but also repolarized the functional status of TAM displaying features of some M1 macrophage subtype with upregulated phagocytosis and tumoricidal activity accompanied by altered expression of monocarboxylate transporter-1, toll-like receptor-2, surface markers: CD11c, interleukin-2 receptor, CD62L, and secreted molecules: nitric oxide, interleukin (IL)-1, IL-6, tumor necrosis factor-α, and vascular endothelial growth factor. Declined tumor cell survival and modulated repertoire of cytokines: interferon-γ, IL-6, IL-10, and transforming growth factor-β in tumor microenvironment indicated their role in polarization of TAM towards proinflammatory state. Bone marrow cell of Listeria-administered tumor-bearing mice showed augmented survival, declined expression of p53 upregulated modulator of apoptosis with an upregulated differentiation into activation responsive bone marrow-derived macrophages along with altered expression of macrophage-colony stimulating factor, macrophage-colony stimulating factor receptor, and granulocyte macrophage-colony stimulating factor receptor. These findings indicate that Listeria infection is associated with an augmented differentiation of macrophages accompanied by tumoricidal activation of TAM.

show abstract

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Augmented Macrophage Differentiation and Polarization of Tumor-associated Macrophages Towards M1 Subtype in Listeria-administered Tumor-bearing Host

Rakesh

Vishvakarma

Mohapatra

et al. 2012

Journal of Immunotherapy

View full text Add to dashboard Cite

show abstract

“…This involves pathophysiologic alterations in the stem cells and their microenvironment, enveloping extracellular matrix and stromal cells, in addition to local and systemic chemokine production [6]. Of importance here are our previous studies showing the relevance of the restoration of both the myelosuppression and the increased splenic EMH for recovering the homeostatic balance in the immunocompromised host, as observed during chronic inflammatory states such as infection and tumors [7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 84%

Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella

Torello¹,

Paredes‐Gamero²,

Fern³

et al. 2016

Med Aromat Plants

View full text Add to dashboard Cite

“…16 In a recent study, we demonstrated that oral b-1,3-glucan has an important immunohematopoietic stimulatory effect in mice infected with Listeria monocytogenes. 17 These findings encouraged our interest in the potential use of b-1,3-glucan as an adjuvant agent for host antitumour responses.…”

Section: Introductionmentioning

confidence: 98%

β‐1,3‐Glucan given orally modulates immunomyelopoietic activity and enhances the resistance of tumour‐bearing mice

Torello

Queiroz

2012

Clin Exp Pharma Physio

View full text Add to dashboard Cite

β-Glucans have been reported to be potent adjuvants in stimulating innate and adaptive immune responses. The aim of the present study was to determine the immunohematopoietic effects of Imunoglucan (HEBRON) following its oral administration to normal and Ehrlich ascites tumour (EAT)-bearing mice. Mice were treated with 250, 500 and 1000 mg/kg per day, p.o., Imunoglucan (β-1,3-glucan extracted from Saccharomyces cerevisae) for 18 consecutive days. Treatment started 10 days prior to and ended 8 days after tumour inoculation. At 500 and 1000 mg/kg per day, Imunoglucan enhanced the life span of EAT-bearing mice and prevented myelosuppression and splenomegaly caused by the tumour by increasing the number of granulocyte-macrophage progenitors in the bone marrow and increasing colony-stimulating activity in the serum. At 500 mg/kg, Imunoglucan restored the reduced ability of stromal cells to display myeloid progenitors in long-term bone marrow cultures of EAT-bearing mice and upregulated the production of interleukin (IL)-6 and IL-1α by these cells, consistent with a higher number of non-adherent cells. Moreover, 500 mg/kg Imunoglucan restored natural killer cell activity in tumour-bearing mice, consistent with the increased production of interferon (IFN)-γ observed. The results of the present study suggest that Imunoglucan given orally indirectly modulates immune activity and probably disengages tumour-induced suppression by producing a higher reserve of myeloid progenitors in the bone marrow in consequence of biologically active cytokine release (colony-stimulating factors, IL-1α, IL-6 and IFN-γ).

show abstract

Immunohematopoietic modulation by oral β-1,3-glucan in mice infected with Listeria monocytogenes

Cited by 17 publications

References 49 publications

Augmented Macrophage Differentiation and Polarization of Tumor-associated Macrophages Towards M1 Subtype in Listeria-administered Tumor-bearing Host

Augmented Macrophage Differentiation and Polarization of Tumor-associated Macrophages Towards M1 Subtype in Listeria-administered Tumor-bearing Host

Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella

β‐1,3‐Glucan given orally modulates immunomyelopoietic activity and enhances the resistance of tumour‐bearing mice

Contact Info

Product

Resources

About