Immunohematology and Hemostasis

Jackson, Karen V.

doi:10.1002/9781118718704.ch3

Cited by 1 publication

(3 citation statements)

References 62 publications

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“…Secondary immunomediated thrombocytopenia is associated with differents agents. Virus (herpes virus, influenza, equine infectious anemia-EIA), bacterial infections (endotoxaemia, neonatal septicemia, Anaplasmaphagocytophilum), neoplasms (lymphosarcoma), immune-mediated hemolytic anemia (IMHA), glomerulonephritis, drugs (penicillin or trimethoprimsulfadoxine), vasculitis and toxins are the principals described [1,47,48]. Another possibility are horses receiving heparin therapy wich may also develop thrombocytopenia [49].…”

Section: Increased Peripheral Destruction Of Plateletsmentioning

confidence: 99%

“…Either excessive consumption or loss through the GI tract in proteinlosing enteropathy causes thrombocytopenia and deficiencies in antithrombin III, have been observed in affected patients. Laboratory diagnosis of DIC include thrombocytopenia (usually < 100.000/µL), prolonged PT, aPTT, low fibrinogen (< 150mg/dL), low ATIII activity and increased FDP sor D-dimers [1]. In horses hemolytic uremic syndrome is produced by acute renal failure with microangiopathicintravasculary hemolysis and disseminated or renal intravascular coagulation [59,60].…”

Section: Increased Consumption and Loss Of Plateletsmentioning

confidence: 99%

“…With platelet aggregation, the granules release their contents by further amplifying platelet aggregation. As a result the platelet plug is formed resulting in hemostasis [1].…”

Section: Introductionmentioning

confidence: 99%

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Interpretation of Platelets in The Horse

2017

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Currently we can consider that, in addition to its role in hemostasis, platelets also participate in other important processes such as thrombosis, inflammation, tissue remodeling and the innate defense mechanisms. The hemostatic activity of platelets includes different events to stop bleeding. Within these functions we can mention the adhesion to the endothelium of the affected blood vessel, the activation, the aggregation, and the release of substances that initiate hemostatic events, and also the providing a phospholipid surface for activation of numerous coagulation factors. Similarly, platelets release multiple growth factors responsible for regulating the growth and division of endothelial cells and fibroblasts. In this way, among other things, angiogenesis and tissue regeneration are favored. Platelets also participate in inflammatory processes by the release of factors that initiate the inflammatory cascade and favor the chemotaxis of neutrophils, monocytes, macrophages, acute phase proteins and target cell signaling. Finally, platelets participate in the immune response by interacting with the complement system and immunoglobulins.

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