Immunoglobulins in tears of normal Indian people.

Dk, Sen; Sarin, G. S.; Mani, Kavaratty Raju; Saha, Kunal

doi:10.1136/bjo.60.4.302

Cited by 25 publications

(10 citation statements)

References 5 publications

(2 reference statements)

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“…Tear IgG levels were relatively low although with large margins. Although the majority of authors [18,[20][21][22] fail to detect IgM in tears, the present study reveals that this immunoglobulin is present both in controls and patients at low concentrations and requires no dilution for detection. We found no reference in the literature to tear immunoglobulins in patients with rheumatoid arthritis with or without KS.…”

Section: Discussionmentioning

confidence: 85%

Lacrimal Immunoglobulins in Rheumatoid Arthritis Patients with or without Sjögren’s Syndrome

Domingo

Coll²,

Ribas-Montobio³

et al. 1997

Ophthalmologica

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The aim of the present study was to analyse immunoglobulin G, A, and M levels in tears of patients with rheumatoid arthritis with or without keratoconjunctivitis sicca (KS) which define Sjögren’s syndrome (SS). Tears were collected from the lower cul-de-sac by capillarity (100–300 μl). Tear IgG, IgA and IgM levels were determined by radial immunodiffusion. Samples diluted 1:10 were used for IgA and IgG and non-diluted ones for IgM. Fifty-three patients with rheumatoid arthritis and 30 healthy control subjects were studied. In all individuals IgA predominated in tears, IgG levels were low but with a very wide range and IgM was present in very low concentrations. The IgG concentration in tears showed statistically significant differences between the control group and that of rheumatoid arthritis and KS. IgG in tears correlated positively with the rose bengal test (r = 0.2848, p < 0.05) and negatively with the Schirmer test (r = –0.3042, p < 0.05). Tear IgG measurement might provide a marker for eye involvement in patients with rheumatoid arthritis and KS which define SS.

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Section: Discussionmentioning

confidence: 85%

Lacrimal Immunoglobulins in Rheumatoid Arthritis Patients with or without Sjögren’s Syndrome

Domingo

Coll²,

Ribas-Montobio³

et al. 1997

Ophthalmologica

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“…An earlier report by the present authors has already described the IgA level among healthy Indian people (Sen et al, 1976). However, for the purpose of the present investigation it was considered advisable to examine a fresh group of healthy persons to serve as concurrent controls for the study of trachomatous patients.…”

Section: Methodsmentioning

confidence: 95%

“…However, for the purpose of the present investigation it was considered advisable to examine a fresh group of healthy persons to serve as concurrent controls for the study of trachomatous patients. Human tear Address for reprints: Dr D. K. Sen, Department of Ophthalmology, Maulana Azad Medical College and Irwin Hospital, New Delhi-110002, India specimens were collected by the technique as described previously (Sen et al, 1976). The details of the cases are given in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Immunoglobulins in tear in trachoma patients.

Dk¹,

Sarin²,

Saha³

1977

British Journal of Ophthalmology

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“…8'101516 There are several reports on age-related changes in the level of tear lysozyme which are conflicting. [8][9][10][11][12][13][14][15][16][17] 8' Some investigators have found that there is no effect of age on the tear lysozyme levels.! ' 16 17 19 Bonavida and Sapse20 found lower levels of tear lysozyme at the upper and lower extremes of age.…”

Section: Resultsmentioning

confidence: 99%

Biological variations of lysozyme concentration in the tear fluids of healthy persons.

Sen¹,

Sarin²

1986

British Journal of Ophthalmology

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Lysozyme, discovered by Fleming,' is widely distributed in nature. It has been found in measurable quantity in tears, saliva, serum, nasal secretions, urine, neutrophils, and macrophages.2 Since alteration in the lysozyme level in human tears has been observed in some ocular diseases,-'2 its measurement can be of considerable diagnostic importance. However, an adequate knowledge of the biological variations is essential for valid comparisons of tear lysozyme levels between healthy and diseased subjects.The present study was undertaken to find out differences, if any, in the tear lysozyme concentration between the two eyes and also the diurnal variation in the same eye. The concentrations of tear lysozyme over a period of time and in relation to age and sex have also been studied. Material and methodsThe study was carried out on healthy Indian subjects belonging to the same racial group. They were either volunteers or had attended the outpatient department of Guru Nanak Eye Centre, New Delhi, for refraction. They had no ocular or systemic disease. All of them had been in the uniform hospital environment for at least two hours prior to sampling.In the first part of the study tear samples were

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Immunoglobulins in tears of normal Indian people.

Cited by 25 publications

References 5 publications

Lacrimal Immunoglobulins in Rheumatoid Arthritis Patients with or without Sjögren’s Syndrome

Lacrimal Immunoglobulins in Rheumatoid Arthritis Patients with or without Sjögren’s Syndrome

Immunoglobulins in tear in trachoma patients.

Biological variations of lysozyme concentration in the tear fluids of healthy persons.

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