Immunoglobulins concentration and B cell counts as severity markers in adult community-acquired pneumonia

Luchsinger, Vivían; Lizama, Luis; Garmendia, María Luisa; Tempio, Fabián; Ruiz, Mauricio; Pizarro, Rolando; Rossi, Patricio; Huenchur, Lucía; Moreno, Cristian; López, Mercedes; Ampuero, Sandra; Larrañaga, Carmen; Avendaño, Luis F.

doi:10.1097/md.0000000000022390

Cited by 5 publications

(7 citation statements)

References 27 publications

(48 reference statements)

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“…Increase of WBC count together with lymphocyte decrease in patients with CAP compared to healthy controls, especially those with sCAP, indicates the natural response to severe infection, which is consistent with previous studies [ 10 , 13 ]. We found that compared to CAP, sCAP was characterized by significantly lower absolute number of B cells, PBMC, Bn cells and Btr cells, significantly lower PBMC subset percentage, as well as percentage of naïve B cells, while percentage of IgM + Bm cells was significantly higher.…”

Section: Discussionsupporting

confidence: 92%

“…In our study, percentage of IgM + Bm cells was significantly higher in CAP and especially sCAP compared to healthy controls. However, other reports indicate that total blood IgM, IgG2 and IgG levels are lower in CAP [ 10 ], as well as some other inflammatory and autoimmune diseases [ 23 ]. This contradiction seems to be related to the previously reported defect in some IgM + Bm cells, which upon re-stimulation with a T cell-dependent antigen fail to differentiate into IgM antibody-secreting cells [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the expression of proteins, such as CD19, CD20, CD24, CD38, CD27, IgD, IgG and IgM, circulating human B cells are typically classified into transitional B cells, naive B cells, memory B cells and antibody-secreting cells [ 7 – 9 ], and B cell subsets of diverse maturation states perform different functions [ 6 ]. A cross-sectional study has reported that B cell count is related to the severity of adult CAP [ 10 ]. A recent study reported that the decreased B-cell percentage was associated with the death risk of COVID-19 patients [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia

Wang

Zhang

et al. 2022

BMC Pulm Med

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Background The role of B cell subsets remained to be elucidated in a variety of immune diseases, though which was used as an effective biomarker for anti-inflammatory or antiviral response. This study aimed to evaluate the early changes of B cell subtypes distribution in elderly patients with community acquired pneumonia (CAP), as well as the association between B cell subtypes and prognosis. Methods This prospective study included elderly patients with CAP, severe CAP (sCAP) and healthy elderly subjects between April 2016 and March 2018. Flow cytometry was used to detect CD3, CD20, HLA-DR, CD24, CD27, CD38, IgM, and IgD. CD20+ B cells were further divided into naïve B cells (Bn), IgM/D+ memory B cells (IgM+ Bm), switched B cells (SwB), and transitional B cells (Btr). Results A total of 22 healthy controls, 87 patients with CAP and 58 patients with sCAP were included in the study. Compared to CAP, sCAP was characterized by significantly lower absolute number of B cells, Bn and Btr, significantly lower Btr and Bn subset percentage, while percentage of IgM+ Bm was significantly higher. Heat map showed Bn and Btr on day 3 and day 7 was negatively correlated with activated partial prothrombin time (APTT), international normalized ratio (INR), sequential organ failure assessment score (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II). After 28-day follow-up, Btr percentage in survival group was significantly higher. Receiver operator characteristic (ROC) curve analysis found that Btr count showed sensitivity of 48.6% and specificity of 87.0% for predicting the 28-day survival, with an area under the ROC curves of 0.689 (p = 0.019). Conclusions Severity and prognosis of CAP in elderly people is accompanied by changes in the B cell subsets. Btr subsets could play prognostic role for a short-term mortality of elderly CAP patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia

Wang

Zhang

et al. 2022

BMC Pulm Med

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“…T lymphocyte counts in the critical and severe groups are significantly lower than those in the mild groups ( p < 0.01). A negative correlation is shown between immune response and severity, similar to other reports ( Lei et al, 2020 ; Luchsinger et al, 2020 ). The absolute number of B lymphocytes and T lymphocytes from COVID-9 patients may be closely related to the severity of the disease.…”

Section: Discussionsupporting

confidence: 91%

The Relationship Between Convergent IGH Signatures and Severity of COVID-19 Patients by Next-Generation Sequencing of B-Cell Repertoire

Cai

Huang

et al. 2022

Front. Microbiol.

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ObjectTo reveal convergent IGH signatures and the association with severity of coronavirus disease 2019 (COVID-19) patients.MethodA total of 25 COVID-19 inpatients were classified into three clinical conditions: mild, severe, and critical. We analyzed convergent IGH signatures by ImmuHub® B-cell receptor (BCR) profiling system.ResultsIGH singleton frequency in patients is significantly lower than that of healthy donors (HDs). The clonality index of IGH in patients is significantly higher than that in HDs. Nevertheless, no significant difference was observed among the three groups. The difference in IGH clonality (top five clones) between post- and pretreatment was significant in the improvement and deterioration groups. Three common public motifs were shared by all COVID-19 patients: ARDYGG, RWYFDY, and YYYYGMDV.ConclusionB cells could recognize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and produce clonal expansion. Patients who had better outcomes after treatment had higher IGH clonality. Three common public motifs—ARDYGG, RWYFDY, and YYYYGMDV—might be used for vaccine development (ChiCTR2000029626).

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“…Previous studies on the association of serum Ig levels with pneumonia prevalence and severity in immunocompetent individuals reported inconclusive results and were performed in adults with a heterogeneous age range ( 12 – 16 ). These studies furthermore had several limitations that potentially restrict extrapolation of results to older individuals from a general population.…”

Section: Introductionmentioning

confidence: 99%

Serum Immunoglobulins, Pneumonia Risk, and Lung Function in Middle-Aged and Older Individuals: A Population-Based Cohort Study

et al. 2022

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IntroductionImmunoglobulins (Igs) play a pivotal role in host defense and prevention of pneumonia. Aging influences serum Ig levels, but the association between Igs and pneumonia in community-dwelling older individuals remains unknown. We evaluated the association of serum IgA, IgG, and IgM with pneumonia and lung function in middle-aged and older individuals.MethodsWe performed Cox and negative binomial regression analyses for the association of Igs with incident pneumonia and pneumonia-related mortality, and recurrent pneumonia respectively. We performed logistic regression analyses for the association between Igs and lung function values. Associations were adjusted for age, sex, smoking, comorbidities, and serum C-reactive protein.ResultsWe included 8,766 participants (median age 62.2 years, 57% women, median follow-up 9.8 years). Higher IgA (hazard ratio [HR]: 1.15; 95% confidence interval [95% CI]: 1.00-1.32) and IgG (HR: 1.13; 95% CI: 1.06-1.19) were associated with an increased pneumonia risk. Higher IgG was associated with an increased risk of pneumonia-related mortality (HR: 1.08; 95% CI: 1.01-1.16) and recurrent pneumonia (incidence rate ratio: 1.04; 95% CI: 1.00-1.09). Higher IgA and IgG were also associated with lower forced expiratory volume in one second (FEV1), lower forced vital capacity (FVC), and an increased odds of preserved ratio impaired spirometry (PRISm, i.e. FEV1 <80% and FEV1/FVC ratio ≥70%). No association was seen with an obstructive spirometry pattern.DiscussionHigher serum IgA and IgG levels were associated with pneumonia, pneumonia-related mortality, and PRISm in middle-aged and older individuals from the general population. Future studies should validate our findings and elucidate underlying pathophysiology.

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Immunoglobulins concentration and B cell counts as severity markers in adult community-acquired pneumonia

Abstract: Supplemental Digital Content is available in the text

Cited by 5 publications

References 27 publications

B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia

B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia

The Relationship Between Convergent IGH Signatures and Severity of COVID-19 Patients by Next-Generation Sequencing of B-Cell Repertoire

Serum Immunoglobulins, Pneumonia Risk, and Lung Function in Middle-Aged and Older Individuals: A Population-Based Cohort Study

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