Immunoglobulin Synthesis In Vitro by Cerebrospinal Fluid Cells in Patients with Meningoencephalitis of Presumed Viral Origin.

Sandberg‐Wollheim, Magnhild

doi:10.1111/j.1365-3083.1975.tb02669.x

Cited by 20 publications

(4 citation statements)

References 12 publications

(11 reference statements)

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“…Although, the impact of B cells and their antibody products in mediating the pathology of MS has long been considered [7–10], their contributions have been more recently highlighted by the demonstration that Rituximab, an anti-CD20 monoclonal antibody that specifically depletes B cells, was a potent immunomodulatory therapy for the treatment of MS [11, 12]. More importantly, however, the efficacy of Rituximab in the treatment of MS patients is independent of secreted antibody since Rituximab does not affect plasma cell frequencies or serum and cerebrospinal fluid (CSF) antibody levels [13].…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of B Cells on T Cell Function in Multiple Sclerosis

Ireland

Monson

2011

Multiple Sclerosis International

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Multiple sclerosis is a chronic debilitating autoimmune disease of the central nervous system. The contribution of B cells in the pathoetiology of MS has recently been highlighted by the emergence of rituximab, an anti-CD20 monoclonal antibody that specifically depletes B cells, as a potent immunomodulatory therapy for the treatment of MS. However, a clearer understanding of the impact B cells have on the neuro-inflammatory component of MS pathogenesis is needed in order to develop novel therapeutics whose affects on B cells would be beneficial and not harmful. Since T cells are known mediators of the pathology of MS, the goal of this review is to summarize what is known about the interactions between B cells and T cells, and how current and emerging immunotherapies may impact B-T cell interactions in MS.

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Section: Introductionmentioning

confidence: 99%

Potential Impact of B Cells on T Cell Function in Multiple Sclerosis

Ireland

Monson

2011

Multiple Sclerosis International

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“…A local (intrathecal) synthesis o f IgM was sug gested by Savory and Heintges (7) and demon strated by Lord et al (3) in a case with absence of serum IgM. Sandberg-Wollheim (6) recently demonstrated an in vitro IgM synthesis from C SF lymphocytes in meningo-encephalitis of presumed viral origin. This paper is an attempt to make precise two important points: (1) the eventual variations o f serum IgM in neurological diseases; (2) the fre quency o f IgM presence in C S F , its origin and its diagnostic value.…”

Section: Sclerosismentioning

confidence: 98%

Serum and Cerebrospinal Fluid IGM in 203 Neurological Patients

Schuller¹,

Delasnerie²,

Helary³

et al. 1978

Eur Neurol

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Simultaneous serum and CSF IgM determinations were made by electroimmunodiffusion in 5 normals and 203 patients. Absent from normal CSF, IgM was found in 56 patients (27%): (1) A blood-CSF transudation was present in 25 patients (12%). IgM seems of no diagnostic value in these cases. (2) A purely local synthesis was demonstrated in 17 patients (8%), concerning proved (bacterial, viral, parasitic) or supposed (multiple sclerosis) persistent infectious aggressions. (3) In the last 14 patients with IgM in CSF, a transudation was associated with a local synthesis of IgG (meningitic pattern). (4) A ratio IgM 10³ /albumin above 10 seems an argument for multiple sclerosis.

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“…In patients with mumps meningitis, speciflc IgG antibodies against mumps virus have been localized to oligocional bands in CSF [9]. Cultured CSF lymphocytes from patients with AM have, in vitro, been demonstrated to produce IgG and IgA and, in a few cases, even IgM [10].…”

mentioning

confidence: 99%

Immunoglobulin‐Producing Cells in Blood and Cerebrospinal Fluid during the Course of Aseptic Meningoencephalitis

Forsberg

Kam‐Hansen

1983

Scand J Immunol

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The protein A plaque assay was used to quantitate the number of IgG-, IgA-, and IgM-producing cells per 20 X 10(3) lymphocytes in cerebrospinal fluid (CSF) and peripheral blood (PB) from 23 patients with aseptic meningoencephalitis (AM) in the acute stage 1-10 days after onset (group I) and during late convalescence after 19-38 days (group II) and in PB from healthy controls. In the acute stage, IgG- and IgM-producing cells were found with significantly higher frequency in both CSF and PB than in the late convalescence. In both patient groups there were more Ig-producing cells in PB than in CSF. The predominant Ig class in PB of AM patients was IgA, just as in healthy individuals. In CSF, IgA- and IgG-producing cells predominated at similar frequencies. In the group I patients, there were positive correlations between numbers of Ig-producing cells of each class and the corresponding CSF Ig index, an indicator of intrathecal Ig synthesis. Since high numbers of Ig-producing cells could be found in CSF that was otherwise normal, enumeration of Ig-producing cells is considered a more sensitive indicator of the immune response intrathecally than measurement of free Igs.

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Immunoglobulin Synthesis In Vitro by Cerebrospinal Fluid Cells in Patients with Meningoencephalitis of Presumed Viral Origin.

Cited by 20 publications

References 12 publications

Potential Impact of B Cells on T Cell Function in Multiple Sclerosis

Potential Impact of B Cells on T Cell Function in Multiple Sclerosis

Serum and Cerebrospinal Fluid IGM in 203 Neurological Patients

Immunoglobulin‐Producing Cells in Blood and Cerebrospinal Fluid during the Course of Aseptic Meningoencephalitis

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