Immunoglobulin subclass deficiency

Hanson, Lars Å.; Söderström, R; Avanzini, Maria Antonietta; Bengtsson, Ulf; Björkander, Janne; Söderström, T

doi:10.1097/00006454-198805001-00005

Cited by 29 publications

(10 citation statements)

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“…Patients with these symptoms are occasionally found to have antibody deficiency. [267][268][269][270][271][272][273][274] In some patients with immune abnormalities and infection-associated asthma, replacement doses of IVIG may eliminate the triggering infections and/or reduce the frequency and severity of pulmonary symptoms. This, in turn, may decrease the symptoms and morbidity of asthma.…”

Section: Use Of Ivig In Atopic Diseases Asthmamentioning

confidence: 99%

Update on the use of immunoglobulin in human disease: A review of evidence

Perez

Orange

Bonilla

et al. 2017

Journal of Allergy and Clinical Immunology

509

462

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Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted.

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Section: Use Of Ivig In Atopic Diseases Asthmamentioning

confidence: 99%

Update on the use of immunoglobulin in human disease: A review of evidence

Perez

Orange

Bonilla

et al. 2017

Journal of Allergy and Clinical Immunology

509

462

View full text Add to dashboard Cite

show abstract

“…Patients who fit these descriptions are occasionally found to have antibody deficiency. [126][127][128][129][130][131][132][133] In some patients with immune abnormalities and infection-associated asthma, replacement doses of IGIV might eliminate the triggering infections, reduce the frequency and severity of their pulmonary symptoms, or both. This in turn might decrease the symptoms and morbidity of asthma.…”

Section: Use Of Igiv In Asthmamentioning

confidence: 99%

Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Orange

Hossny

Weiler³

et al. 2006

Journal of Allergy and Clinical Immunology

564

420

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“…Several rheumatic illnesses may develop in patients with primary or acquired immunologic disorders. Individuals with primary defects in B cell antibody production, such as common variable immunodeficiency or selective IgA deficiency, and those with defects of complement components, have an increased prevalence of SLE or other autoimmune diseases [4,5,20]. Our patient had an IgA and IgG2 subclass deficiency at the time of diagnosis, moreover a low B cell count was found.…”

Section: Discussionmentioning

confidence: 66%

Severe systemic disorder in a 5 months old child: A case of early systemic lupus erythematosus?

Grabhorn

Englert

Geisler

et al. 2015

J Pediatr Infect Dis

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A 5-month-old girl developed intractable cerebral seizures and a global mental and motor retardation after a scheduled hexavalent vaccination. In the following years, recurrent fever, hepatosplenomegaly, and a pancytopenia indicated other organ system involvement. At the age of 4 years the diagnosis of a severe systemic autoimmune disorder was made, defined by highly elevated antinuclear antibody (ANA), smooth muscle antigen (SMA), extractable nuclear antigen, and decreased complement factors C3c and C4. Moreover, a low B cell count and an IgA and IgG2 subclass deficiency were found. After initiation of an immunosuppressive therapy as well as monthly intravenous immunoglobulin application, the clinical situation improved dramatically. Despite therapy and clinical improvement, there is still an intermittent elevation of ANA and SMA as well as decreased complement C4, a persistent low B cell count and an IgA deficiency. We propose the possibility of an underlying primary immunodeficiency with subsequent development of a severe systemic autoimmune disease possibly triggered by routine vaccination. The clinical features and laboratory tests are consistent with a systemic lupus erythematosus or lupus-like syndrome.

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Immunoglobulin subclass deficiency

Cited by 29 publications

References 0 publications

Update on the use of immunoglobulin in human disease: A review of evidence

Update on the use of immunoglobulin in human disease: A review of evidence

Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Severe systemic disorder in a 5 months old child: A case of early systemic lupus erythematosus?

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