Abstract:There has been an association between post solid organ transplant (SOT) hypogammaglobulinemia and infections, but the benefit of immunoglobulin (Ig) replacement has been less clear. We hypothesize that (1) only a subset of patients with post-SOT hypogammaglobulinemia have impaired antibody responses; (2) empiric Ig replacement before checking antibody responses may commit some patients to unnecessary therapy; and (3) patients with impaired antibody responses have fewer infections after replacement. METHODS: Ep… Show more
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