Immunoglobulin isotypes of lactating Holstein cows classified as high, average, and low type-1 or -2 immune responders

Heriazon, Armando; Hamilton, Korinne; Huffman, Jennifer; Wilkie, B.N.; Sears, William; Quinton, M.; Mallard, Bonnie A.

doi:10.1016/j.vetimm.2011.08.023

Cited by 21 publications

(13 citation statements)

References 41 publications

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“…The present study indicated occurrence of a highly significant increase in rates of the serum IgG and IgM 2 week after treatment of cattle by Celmanax (table, 2), a finding which came in agreement with that reported in some previous investigations after dietary supplementation of mannan oligosaccharides in different species (Newman and Newman, 2001;O'Quinn et al, 2001;Franklin et al, 2002;Spearman, 2004). Increases in the level of both IgG and IgM two weeks after treatment and two weeks after parturition in treated cattle by Celmanax than non treated might be attributed to immunostimulating effect of Celmanax (Baines et al, 2011),but sudden decrease in the level of both IgG and IgM at parturition in treated and control group attributed to transport of immunoglobulin from blood into mammary gland secretion in the period around calving (Mallard et al, 1998 ;Heriazon et al, 2011) which can be necessary for calf health .…”

Section: Disscussionmentioning

confidence: 99%

Improvement of the Reproductive Performance of Dairy Cows during the Transition Period

Desouky¹

2014

AJVS

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Key words: ABSTRACT:Reproductive performances Dairy cows Immunostimulant Celmanax Transition periodThe present study is a trial to improve the reproductive performance of dairy cows following the administration of an immune-stimulant prebiotic drug during the transition period. A total number of 30 dairy cows, 3-8 years old and 1-6 parities, were assigned into two comparable groups: 20 cows were taken Celmanax, as a immune-stimulant prebiotic drug, and 10 cows were left as control. The obtained results showed a non-significant reduction in the rate of retained placenta and the number of service/conception, significant shortness in time of uterine involution and the days open as well as improvement of the conception rate for the treated rather than for the non-treated dairy cattle. The serum IgG and IgM increased, while the serum Nitric oxide decreased from the 30 th day before to the 15 th day after parturition in the treated group. From the present study, it can be concluded that supplementation of dairy cattle by Celmanax, as an immunopotentiating factor, helps in improvement of the reproductive performance of the dairy cattle incorporation with the increase in the serum immune-stimulant responses of IgG / IgM and the decrease in the serum nitric oxide.

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Section: Disscussionmentioning

confidence: 99%

Improvement of the Reproductive Performance of Dairy Cows during the Transition Period

Desouky¹

2014

AJVS

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“…Selection for enhanced immune response (IR) is expected to decrease the incidence of disease and improve health in dairy cattle (Abdel-Azim et al, 2005;Mallard et al, 2011). The use of antibody-mediated (AMIR) and cell-mediated IR (CMIR) as indicator traits of adaptive IR in cattle and other species has proved useful in identifying individuals with high or low IR profiles (Mallard et al, 1992;Sarker et al, 2000;Heriazon et al, 2011). In a previous study that evaluated antibody responses in Canadian Holsteins it was found that in 2 out of 3 herds tested, cows with a high-AMIR phenotype had a lower occurrence of mastitis (Wagter et al, 2000).…”

Section: Short Communicationmentioning

confidence: 99%

Short communication: Association of disease incidence and adaptive immune response in Holstein dairy cows

Thompson-Crispi

Hine

Quinton

et al. 2012

Journal of Dairy Science

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The objective of this study was to use previously calculated estimated breeding values for cell- (CMIR) and antibody-mediated immune responses (AMIR) to determine associations between immune response (IR) and economically important diseases of dairy cattle. In total, 699 Holsteins were classified as high, average, or low for CMIR, AMIR, and overall IR (combined CMIR and AMIR), and associations with mastitis, metritis, ketosis, displaced abomasums, and retained fetal membranes were determined. The incidence of mastitis was higher among average cows as compared with cows classified as high AMIR [odds ratio (OR)=2.5], high CMIR (OR=1.8), or high IR (OR=1.8). Low-CMIR cows had a higher incidence of metritis (OR=11.3) and low-IR cows had a higher incidence of displaced abomasum (OR=4.1) and retained fetal membrane (OR=2.8) than did average responders. Results of this study show that cows classified as high immune responders have lower occurrence of disease, suggesting that breeding cattle for enhanced IR may be a feasible approach to decrease the incidence of infectious and metabolic diseases in the dairy industry.

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“…Jezek et al (2012) found that quality of colostrum was positively correlated with the levels of IgM, IgA and IgG in the calves' serum in the first week and with the IgG in the fourth week of life. Also, Heriazon et al (2011) indicated that the immune status of a cow during the transition period importantly influences passive immunity and health status of a newborn calf due to mechanisms that allow the transport of immunoglobulins and cells from blood plasma into mammary gland secretions. Moreover, Krakowski et al (1999) reported that the colostrum from mares supplemented with levamisole showed higher contents of IgG and IgM compared with the colostrum from unsupplemented mares, in additions to higher concentration of immunity in foals from dams supplemented with levamisole.…”

Section: Humoral Immune Response Of Calvesmentioning

confidence: 99%

Improving the Immune and Health Status and Blood Constituents of Egyptian Buffaloes and their Offspring in Response to Treating Dams with Selenomethionine and Levamisole

El-Hawary¹,

El-Hady²

2018

Journal of Animal and Poultry Production

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The present study was conducted to evaluate the effect of treating Egyptian buffaloes with some immunopotentiators as selenomethionine and levamisole HCl separately or in combination, during the late stage of pregnancy and early lactation period, on immune and health status and blood constituents of the dams and their offspring as well as growth performance of their calf. Total of 28 Egyptian buffaloes weighing 600 ± 50 kg in 2 nd-4 th lactation season at late stage of pregnancy (60 days before parturition) were selected to carry out this study. All experimental animals were randomly allocated in randomized design to four similar experimental groups (7 buffaloes / each). Animals in the 1 st group were without treatment and served as a control group, while those in the 2 nd group were orally administrated with 0.9 mg/kg of DM twice weekly of selenomethionine (Se-Met). The 3 rd group were subcutaneously injected with 0.5 mg/kg of BW/week of levamisole HCl (LEV) and the 4 th group were orally administrated with 0.9 mg / kg of DM twice weekly of selenomethionine plus 0.5 mg/kg of BW/week, subcutaneously of levamisole HCl (Se-Met+LEV) respectively, during 60 days pre-and post-partum. The obtained results showed that blood plasma TP, AL, T 3 and T 4 hormones, selenium and glucose concentrations as well as activity of transferases enzymes (ALT and AST) and antioxidant enzymes (GSH and SOD) were improved (P<0.05) in dams that administrated with Se-Met, LEV and Se-Met+LEV and their calf compared with untreated dams and its calves. The best (P<0.05) values recorded with dams received Se-Met+LEV together and their newborn calves. Administration of Se-Met, LEV and their combination Se-Met+LEV to dams achieved significantly (P<0.01) enhanced levels of immunoglobulins IgA, IgM and IgG, and significantly (P<0.01) reduced levels of nitric oxide and cortisol in blood plasma of dams and their newborn calves as compared to the control dams and their offspring. The greatest (P<0.01) values of immunoglobulins IgA, IgM and IgG and least (P<0.01) values of nitric oxide and cortisol were detected in dams administrated with Se-Met+LEV together and their calf. Also, dams treated with a combination of Se-Met+LEV (G 4) recorded significantly (P<0.01) increased concentrations of all immunoglobulins fractions (IgA, IgM and IgG) in their colostrum as compared to the control dams or dams treated with Se-Met (G 2) or LEV (G 3) separately. Moreover, there were no recorded cases of newborn affection between calves delivered from all administrated dams compared with calves delivered from the control dams that shows more severe pneumonia and enteritis as a result of which two calves (28.57%) died in the first month of life. Average birth and weaning weights and daily gain of buffalo calves were significantly (P<0.05) higher by Se-Met, LEV and Se-Met+LEV administration to their dams, begin the highest (P<0.05) values of birth and weaning weights and daily gain of calf produced from buffalo dams received Se-Met+LEV together (G 4). In conclusion, admin...

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Immunoglobulin isotypes of lactating Holstein cows classified as high, average, and low type-1 or -2 immune responders

Cited by 21 publications

References 41 publications

Improvement of the Reproductive Performance of Dairy Cows during the Transition Period

Improvement of the Reproductive Performance of Dairy Cows during the Transition Period

Short communication: Association of disease incidence and adaptive immune response in Holstein dairy cows

Improving the Immune and Health Status and Blood Constituents of Egyptian Buffaloes and their Offspring in Response to Treating Dams with Selenomethionine and Levamisole

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