Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses

Abstract

The early immunoglobulin repertoire of neonatal foals comprised IgGa, IgG(T), and IgA; endogenous synthesis of IgGb could not be detected until 63 days after birth. The restricted repertoire of immunoglobulins in foals may influence humoral immune responses to vaccination.

The Complete Map of the Ig Heavy Chain Constant Gene Region Reveals Evidence for Seven IgG Isotypes and for IgD in the Horse

“…In the current study the expression of IGHG7 mRNA was detected in equine PBMC. The relative expression ratio of the IGHG7:IGHG4 genes was 1:1.6, suggesting that the IgG7 might be present in serum of adult horses in a high concentration, similar to that of IgG4, as detected by mAbs (42). It must be noted that the predicted amino acid sequence of the IgG7 H chain constant region shares a very high homology to that of IgG4.…”

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System

“…Together eqIgG4 and eqIgG7 are the most prevalent forms of IgG in serum and are also found in mucosal secretions (37). Furthermore, both subclasses are able to stimulate a strong respiratory burst from equine peripheral blood leukocytes and effectively activate complement via the classical pathway (16).…”

Experimental investigations to the immune response of foals and adult horses to tetanus toxoid using the Fassisi TetaCheck®

“…Dazu kommt, dass Absetzfohlen auch erst gegen Ende ihres ersten Lebensjahres mit der Synthese des kompletten, funktionellen Sets der erforderlichen Subisotypen aus der Gammaglobulinfraktion auf parenteralen Antigenstimulus reagieren können, also erst zu diesem Zeitpunkt hinsichtlich ihres Immunstatus dem erwachsenen Pferd vergleichbar sind (Jeffcott 1974, Thein 1979, Thein 1983, Sheoran et al 2000, Wilson et al 2001, Holznagel et al 2003. Die unterschiedliche Rolle der einzelnen IgG-Subisotypen in der Abwehr bakterieller wie viraler Infektionen ist annähernd bekannt.…”