Immunoglobulin Gene Use by Naturally Occurring Cold Agglutinins

Polylactosamines, there’s more than meets the “Ii”: a review of the I system

“…Early studies using the 9G4 MAb showed that only a fraction of naturally occurring polyclonal anti-Ii carried the V H 4-34 gene segment. 82,86 This was also supported by the inability of MAb 9G4 to inhibit hemagglutination with polyclonal anti-I/i. 86 Naturally occurring anti-Ii uses a mix of V H segments from the V H 3 and V H 4 families.…”

“…82,86 This was also supported by the inability of MAb 9G4 to inhibit hemagglutination with polyclonal anti-I/i. 86 Naturally occurring anti-Ii uses a mix of V H segments from the V H 3 and V H 4 families. 86 V H 3 and V H 4 family genes account for 65 percent of the total B-cell repertoire and nearly 78.7 percent of all circulating immunoglobulin.…”

“…86 Naturally occurring anti-Ii uses a mix of V H segments from the V H 3 and V H 4 families. 86 V H 3 and V H 4 family genes account for 65 percent of the total B-cell repertoire and nearly 78.7 percent of all circulating immunoglobulin. 85 Infection may increase the concentration of V H 4-34 antibody.…”