Immunoglobulin G4‐related disease in a dog

Abstract

Immunoglobulin G4-related disease (IgG4-RD), which affects many organ systems, has been recognized as a distinct clinical entity in human medicine for just over a decade but has not been previously identified in dogs. In humans, IgG4-RD is characterized by diffuse IgG4-positive lymphoplasmacytic infiltrates that commonly lead to increased serum concentrations of IgG4 and IgE, peripheral eosinophilia, tumorous swellings that often include the parotid salivary glands, obliterative phlebitis, and extensive fibrosis. Herein we describe the diagnosis, clinical progression, and successful treatment of IgG4-RD in an 8-year-old female spayed Husky mixed breed dog.Immunoglobulin G4-related disease should be considered as a differential diagnosis for dogs with vague clinical signs, lymphoplasmacytic swellings, restricted polyclonal gammopathy, eosinophilia or some combination of these findings.

Light chain myeloma and detection of free light chains in serum and urine of dogs and cats

“…9 Urinary fLC concentration was Table S2). 8,10,11 Feline IF used an identical protocol and feline-specific reagents that targeted WS, IgG, IgA, and IgM heavy chains and LC (see Table S2).…”

Polyclonal B‐cell lymphocytosis in English bulldogs

“…Agarose gel PE and IF were performed at Colorado State University to evaluate immunoglobulins, as previously described. 15 English bulldog cases had significantly higher B-cell CD21 expression than non-bulldog controls (P < .001), English bulldog controls (P < .001) and small breed BCLL cases (P < .001). Comparing nonbulldog and English bulldog controls, English bulldog controls had significantly lower CD25 and CD21 expression (P = .003 and P = .02, respectively).…”

“…The CSU-CI routine PARR assay was performed as previously described. 7,15 PARR results were interpreted as clonal, polyclonal, or restricted polyclonal by the rubric provided in Table 1. These criteria were internally validated and apply only to these primers and cycling conditions when analyzed by fragment analysis methods, and therefore, are not applicable for other assays and laboratories.…”

Diagnostic performance of routine electrophoresis and immunofixation for the detection of immunoglobulin paraproteins (M‐Proteins) in dogs with multiple myeloma and related disorders: Part 2—Toward improved diagnostic performance

“…The human and veterinary literature suggests that abundant polyclonal IgG4 can confound the detection of M-protein. 7 Polyclonal IgG4 travels as a fairly restricted band which can be confused for an M-protein. 7,18,19 Lack of heavy chain labeling in routine IF panels posed challenges for the three IgG4 secretory neoplasms, but the The SPE and IF from the inflammatory bowel disease case with a marked IgG4 restriction were morphologically similar to reported human and canine IgG4-RD cases.…”

“…7 Polyclonal IgG4 travels as a fairly restricted band which can be confused for an M-protein. 7,18,19 Lack of heavy chain labeling in routine IF panels posed challenges for the three IgG4 secretory neoplasms, but the The SPE and IF from the inflammatory bowel disease case with a marked IgG4 restriction were morphologically similar to reported human and canine IgG4-RD cases. 7,18,19 This autoinflammatory condition presents with multiple syndromes that have the common thread of an IgG4 increase, plasmacytosis, fibroplasia, and variable eosinophilia.…”