Immunoglobulin G4-Related Disease: A Case of Autoimmune Pancreatitis With Pulmonary Tuberculosis as Proposed Catalyst

Skrove, Jamie L.; Sandoval, Fiorella Calderon; Le, Bruce; Sobrado, Javier; Rosen, Seth

doi:10.14309/00000434-201510001-00239

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“…Only a few cases have reported the coexistence of TB and AIP as well as the potential mechanism, most of whom had type 1 AIP or IgG4-related diseases. [38][39][40] A study identified crosstalk between T-helper 17 cells and neutrophils mediated through interleukin (IL)-17A as a potential mechanism for the recruitment and subsequent destruction of neutrophils into ductal and glandular blast cells, which may be the pathognomonic for type 2 AIP. 41 TB also causes an imbalance of T-and B-lymphocytes and up to 96.7% of differentially expressed genes in TB overlap with autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

“…All TB infections in our study were detected before the diagnosis of IBD, which excluded opportunistic infections due to medical treatment. Only a few cases have reported the coexistence of TB and AIP as well as the potential mechanism, most of whom had type 1 AIP or IgG4‐related diseases 38–40 . A study identified crosstalk between T‐helper 17 cells and neutrophils mediated through interleukin (IL)‐17A as a potential mechanism for the recruitment and subsequent destruction of neutrophils into ductal and glandular blast cells, which may be the pathognomonic for type 2 AIP 41 .…”

Section: Discussionmentioning

confidence: 99%

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Autoimmune pancreatitis associated with inflammatory bowel diseases: A retrospectively bidirectional case–control study in China

Bai

Ruan

et al. 2023

J of Digest Diseases

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AimAutoimmune pancreatitis (AIP) is a rare and enigmatic immune‐mediated inflammatory diseases associated with inflammatory bowel disease (IBD). We aimed to describe the prevalence, characteristics, and associated factors of AIP‐IBD patients in China.MethodsWe performed a retrospective bidirectional case–control study from 1998 to 2021. The diagnosis of IBD was based on the European Crohn's and Colitis Organisation guidelines and of AIP was based on the International Consensus Diagnostic Criteria. IBD controls were matched by age (±1), sex, and IBD type at a ratio of 1:4, while AIP controls were matched by the frequency of AIP types.ResultsThe age‐standardized prevalence of AIP‐IBD patients in the IBD and AIP population were 292.04 and 8151.93 per 100 000, respectively. IBD patients had a higher risk of suffering AIP compared to non‐IBD patients (OR: 8.4, CI: 4.7–14.9, p < 0.0001), as well as AIP patients developing IBD compared to general population in China. The mean age at diagnosis of IBD was 34.8, and of AIP was 50. Seven cases were first diagnosed with IBD, and the average IBD duration was 94.8 months, while 26.1 months for AIP. Independent factors associated with AIP was tuberculosis infection (p < 0.0001). The occult blood test (p = 0.008) was independently associated with IBD.ConclusionsWe found most AIP‐IBD patients had UC or type 2 AIP. The IBD population is more likely to develop AIP compared to the general population, vice versa. Tuberculosis infection were associated with AIP, and occult blood test was associated with IBD.This article is protected by copyright. All rights reserved.

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