Immunoglobulin G4 (IgG4)-Positive Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma and Idiopathic Orbital Inflammation

Sohn, Eun Jung; Ahn, Hee Bae; Roh, Mee Sook; Jung, Woo Jun; Ryu, Won Yeol; Kwon, Yoon Hyung

doi:10.1097/iop.0000000000000965

Cited by 17 publications

(11 citation statements)

References 39 publications

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“…At present, the pathogenesis of IgG4-RD developing into lymphoma is still unclear. Studies have shown that it may be related to chronic antigenic stimulation that drives lymphoid proliferation, and the residue of reactive lymphoid follicles may provide conditions for malignant development (8). Yuka (11) et al reported a patient with diffuse large B cell lymphoma that developed from IgG4-RD and concluded that chromosome t (14; 19) (q32; Q13.1) translocation may be associated with malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas

Wang

et al. 2021

Front. Oncol.

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Purpose: The clinical characteristics and prognoses of immunoglobulin G4-positive (IgG4+) and IgG4-negative (IgG4−) lacrimal lymphomas were comparatively analyzed to screen for clinical indicators with differential diagnostic significance.Methods: This was a retrospective and single-center clinical study. From June 2011 to June 2018, clinical data of 39 patients with lacrimal lymphoma, diagnosed by histopathology were collected from the Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University.Results: According to inclusion and exclusion criteria, 30 (76.9%) were in the IgG4− group and 9 (23.1%) were in the IgG4+ group. In the IgG4+ group, the sex ratio of male to female was 2:1 and the mean age was 56.67 ± 13.29 years old. In the IgG4− group, the sex ratio of male to female was 3.29:1 and the mean age was 61.47 ± 12.87 years old. Statistical analysis of the clinical indicators showed significant differences between the two groups in affected eye, preoperative history of glucocorticoids, ocular nerve thickening, the expression of serum IgG4 and prognosis (P < 0.05). There was no significant statistical difference in laboratory indicators between the two groups, including C3, C4, RF, ASO, CRP, IgA, IgM, IgG, IgG1, IgG2, and IgG3 (P > 0.05). The event-free cumulative percentages at 3 and 5 years for the 39 lacrimal lymphomas were 81.1 and 62.4%, respectively, with recurrence and death as end events. In 34 lacrimal gland MALT lymphoma cases, the event-free cumulative percentages at 3 and 5 years were 84.4 and 69.1%, respectively. In the IgG4+ and IgG4− groups, the event-free cumulative percentages at 3 years were 75.0 and 87.7%, respectively. The event-free cumulative percentage at 5 years was 62.6% in the IgG4-group and insignificant in the IgG4+ group. There was no statistical difference in event-free cumulative percentage between the two groups (P = 0.983).Conclusion: The pathogenesis and disease characteristics of IgG4-positive lacrimal lymphoma may differ from IgG4-negative lacrimal lymphoma, but the positive expression of IgG4 may not have significant influence on the recurrence of lacrimal lymphoma.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas

Wang

et al. 2021

Front. Oncol.

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“…5). 25,28,[82][83][84][85][86][87][88][89][90][91] MALT lymphoma is most common in the salivary glands, especially among patients with Sjögren syndrome, in which the risk of developing lymphoma is 5-20-fold higher than the general population. 92,93 Early MALT lymphoma lesions arising in the salivary glands consist of 'collars' of B-cells, often with a monocytoid appearance, arranged around frequently obliterated ducts; this feature is not observed in myoepithelial sialadenitis of Sjögren syndrome, when it is not associated with lymphoma.…”

Section: Head and Neckmentioning

confidence: 99%

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Nakamura

Ponzoni

2020

Pathology

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“…Ohno et al (8) revealed that the expression of various cytokine mRNAs of IgG4-RD and IgG4 (+) MZL exhibited statistically the same pattern and suggested that IgG4 (+) MZL might develop malignant lymphoma against the background of IgG4-RD. Some researchers have suggested that a tissue biopsy and IgG4 immunostaining are required in all cases, as IgG4-positive MALT lymphoma may develop from preexisting IgG4positive chronic inflammatory lesions (9). Importantly, when a diagnosis of IgG4-RD is established, the lesion should be assessed to determine whether or not it exhibits an MZL component.…”

Section: Discussionmentioning

confidence: 99%

Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease

et al. 2021

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A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. The lesions shrank following the administration of steroids. A rebiopsy confirmed lung adenocarcinoma, and its background showed IgG4-positive cells a year later. IgG4-related diseases require careful follow-up because they can be complicated by malignancy.

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Immunoglobulin G4 (IgG4)-Positive Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma and Idiopathic Orbital Inflammation

Cited by 17 publications

References 39 publications

Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas

Clinical Features and Prognoses of IgG4-Positive and IgG4-Negative Lacrimal Lymphomas

Marginal zone B-cell lymphoma: lessons from Western and Eastern diagnostic approaches

Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease

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