Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes

Abstract

of OS factors in this subgroup. Overall, the prognostic value of KIR3DL2 expression in .10% of skin lymphoid cells was detected in the entire cohort but requires further prospective investigation, especially in patients with non-MF/SS CTCL. Altogether, these results identified significant KIR3DL2 expression in all CTCL subtypes, thus expanding the number of candidates for KIR3DL2-targeted therapy. In future clinical studies of IPH4102, patients with all CTCL subtypes should therefore be included. Translational studies of KIR3DL2 involvement in noncutaneous peripheral T-cell lymphomas will also be required to examine whether patients with nonprimary CTCL could benefit from KIR3DL2-targeted therapy. It will also be necessary to assess prospectively whether the clinical effect of IPH4102 is related to the percentage of KIR3DL2 expressing lymphoid cells to optimize the treatment of advanced CTCL.

IgG-mediated immune suppression in mice is epitope specific except during high epitope density conditions

“…Recent elegant experiments of IgG-mediated suppression in mice immunized with allogeneic erythrocytes (murine RBC expressing transgenic human blood group antigens) arrive at the same conclusions as experiments in mice immunized with SRBC: neither requires FcγRs 10 , 13 , 15 , 32 , 33 nor clearance 11 , 12 , 48 – 50 , there is an additive suppressive effect of several monoclonal antibodies recognizing different epitopes 14 , 36 , and polyclonal IgG preparations are more efficient than monoclonal IgG antibodies 8 , 14 . In humans there is no strict correlation between clearance and prevention of anti-D alloimmunization 48 , 54 , 55 and, as mentioned above, several studies in mice arrive at the same conclusion 11 , 12 , 49 , 50 . Finally, anti-D administered after transfusion of RhD + erythrocytes 56 as well as IgG anti-SRBC administered several days after SRBC 9 , 19 , 32 , 47 effectively inhibit immunization.…”

“…This would lead to lack of continued B cell stimulation and result in the reported cessation of antibody production. Other observations not compatible with a major role for clearance are that the ability of IgG to suppress does not always correlate with the ability to induce clearance 11 , 12 , 48 – 50 . Moreover, after administration of IgG anti-SRBC and SRBC, an antibody response to the IgG molecule can be induced although the antibody response to SRBC is efficiently suppressed 51 , 52 .…”