Immunoglobulin for Concurrent Guillain-Barré and Immune Thrombocytopenic Purpura

Zeidman, Lawrence A.; Fahey, Christopher D.; Grinblatt, David L.; Harsanyi, Krisztina

doi:10.1016/j.pediatrneurol.2005.06.012

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…On the other hand, it is also considered that some infectious agents including HP, CMV or varicella-zoster virus is related to disease development in some patients with ITP (10). Interestingly, previously reported patients with GBS and ITP (3)(4)(5)(6)(7)(8) as well as the present patient had preceding URI. Although the mechanism of association with GBS/FS and ITP is unclear, there is the possibility that a certain infectious agent causing URI may have epitopes of both ganglioside constituent of nerve tissue and platelet-surface glycoprotein, leading to the cooccurrence of GBS/FS and ITP.…”

Section: Discussionsupporting

confidence: 71%

“…Immune thrombocytopenic purpura (ITP) is also considered an autoimmune disorder characterized by platelet depletion and mucocutaneous bleeding (2). Although associations between GBS and ITP have been reported (3)(4)(5)(6)(7)(8), there have not been any reports of FS associated with ITP. We describe a patient with FS and ITP that developed after upper respiratory infection (URI).…”

Section: Introductionmentioning

confidence: 99%

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Fisher Syndrome Associated with Immune Thrombocytopenic Purpura

et al. 2011

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We describe a 51-year-old man with Fisher syndrome (FS) and immune thrombocytopenic purpura (ITP) that developed after upper respiratory infection (URI). Laboratory investigations demonstrated immunoglobulin (Ig) G class of anti-GQ1b autoantibody and reduced platelet count with platelet-associated IgG, which spontaneously improved in parallel with neurologic symptoms. Thus the possible association of ITP should be considered when encountering a patient with FS. This patient suggests that there may be a certain infectious agent causing URI, leading to the co-occurrence of FS and ITP.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Fisher Syndrome Associated with Immune Thrombocytopenic Purpura

et al. 2011

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“…This explains why patients with one autoimmune disease are likely to develop other disorders of autoimmune nature. Immune thrombocytopenic purpura (ITP), Guillain-Barre syndrome (GBS), and Hashimoto's thyroiditis (HT) are triggered by environmental factors, particularly infectious agents, in a genetically predisposed individual [1,2].…”

Section: Introductionmentioning

confidence: 99%

Concurrent immune thrombocytopenic purpura and Guillain‐Barre syndrome in a patient with Hashimoto's thyroiditis

Kohli

Bleibel

2007

American J Hematol

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Immune thrombocytopenic purpura (ITP), Guillain-Barre syndrome (GBS), and Hashimoto's thyroiditis (HT) are autoimmune disorders caused by impaired self-tolerance mechanisms triggered by interaction between genetic and environmental factors. ITP is an immune-mediated destruction of platelets resulting in mucocutaneous bleeding, GBS is an ascending motor paralysis caused by an inflammatory demyelination of peripheral nerves, and HT is characterized by autoimmune-mediated destruction of the thyroid gland. The concurrent development of ITP and GBS has only rarely been reported in the literature, and GBS itself rarely occurs with other autoimmune disorders. We present a 21 year-old patient with known Hashimoto's hypothyroidism that simultaneously developed GBS and ITP after an upper respiratory tract infection. To the best of our knowledge, this is the first reported case of these three autoimmune disorders in the same patient. This points to a possible common genetic predisposition to these disorders. Am. J. Hematol. 82:307-308, 2007. V V C 2006 Wiley-Liss, Inc.

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“…Without any evidence of a preceding infection, this case could well be the 11th example in the literature on the coexistence of ITP and GBS [2][3][4][5][6][7][8][9][10][11]. In contrast with the current case, however, in the already reported cases of such an association, both GBS and ITP developed simultaneously.…”

mentioning

confidence: 56%

“…In contrast with the current case, however, in the already reported cases of such an association, both GBS and ITP developed simultaneously. In addition, our patient developed a GBS clinical picture with normal platelet count after treatment with immunoglobulins, which has shown efficacy in previous cases associating GBS and ITP [10]. It is therefore tempting to propose a role for rituximab in the development of GBS in this patient.…”

mentioning

confidence: 63%