Immunoglobulin E plays an immunoregulatory role in lupus

Abstract

Dema et al. show evidence that deficiency of IgE delays lupuslike disease development and severity, as demonstrated by reduced autoantibody production and amelioration of organ pathologies. Loss of IgE causes a striking decrease in innate immune cell infiltration in secondary lymphoid organs and decreased activation of T cells and basophils.

Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity

“…Specific autoantibody isotypes are present in different diseases, with IgA antibodies present in antiphospholipid syndrome and IgE autoantibodies present in SLE (82)(83)(84). IgM and IgG autoantibodies are the most abundant.…”

Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency

“…Indeed, both total IgM and MDA-LDL-specific IgM are inversely associated with cardiovascular disease complications in individuals of the AngloScandinavian Cardiac Outcomes Trial. 29 Interestingly, recent work indicates that IgE promote lupus like autoimmunity in mice 30 and that the presence of autoreactive IgE positively associates with disease activity in systemic lupus erythematosus (SLE) patients. 31 Notably, lupus-prone mice lacking sIgM develop enhanced autoimmune pathology compared with their controls.…”

Lupus pathogenesis: role of IgE autoantibodies

“…Growing evidences suggest that the pathogenic role of IgE antibodies is not restricted only to allergy but they might have a role in other inflammatory and autoimmune conditions as well [3,4]. The presence of IgE autoantibodies to dsDNA has been reported previously in several lupus patients [5][6][7]. Recent report in mice has shown that dsDNA-specific IgE (dsDNA-IgE) plays a significant role in the progression of lupus-like disease.…”