Immunoglobulin E and G responses to pertussis toxin in children immunised with adsorbed and non-adsorbed whole cell pertussis vaccines

Duchén, Karel; Granström, Marta; Hedenskog, Staffan; Blennow, Margarate; Björkstén, Bengt

doi:10.1016/s0264-410x(97)00067-4

Cited by 16 publications

(13 citation statements)

References 15 publications

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“…It is a potent protein exotoxin of Bordetella pertussis with several immunological activities including a polyclonal mitogenic stimulation of T-lymphocytes and stimulation of antigen-speci®c IgE antibody production [18,19,25]. Both pertussis disease and pertussis vaccines have been shown to enhance the development of pertussis toxin speci®c immunoglobulin E antibodies (PT-IgE) [7,14,22,24]. Previous studies have shown the association between local side-eects and high levels of IgE antibodies to tetanus and diphtheria toxoids after immunization [16,17].…”

Section: Introductionmentioning

confidence: 99%

Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization

Edelman¹,

Malmström

He³

et al. 1999

European Journal of Pediatrics

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Local reactions and pertussis toxin specific immunoglobulin E antibodies (PT-IgE) were investigated in healthy children following primary and booster immunization with a combined diphtheria tetanus acellular pertussis vaccine (DTPa) including pertussis toxin, filamentous haemagglutinin and pertactin. A primary series of DTPa was administered to 150 infants, and 104 of them received a booster dose of DTPa combined with inactivated polio vaccine at 2 years of age. PT-IgE was measured in serum samples from 72 children using a modified nitrocellulose RAST. Primary immunization was associated with low incidence of local reactions (1%-5%). After the booster dose 21% of children had a local reaction >/=20 mm. Local reactions after the booster dose tended to be more common in children who had experienced reaction at primary immunization. PT-IgE was detected in 18% and 86% of children following primary and booster vaccinations, respectively. Allergic and non-allergic children did not differ in PT-IgE responses. After primary immunization, elevated PT-IgE levels were found more often in children with a family history of allergy than in those without known allergy in the family. Children with local reactions had significantly higher pre- and post-booster PT-IgE levels and median post-booster pertactin IgG and diphtheria-IgG levels than children without local reactions. Conclusion Acellular pertussis immunization induces IgE antibodies to pertussis toxin, especially after booster vaccination. The higher median pre- and post-booster levels of pertussis toxin specific immunoglobulin E and post-booster levels of IgG to pertactin and diphtheria in children with local side-effects reflect a multifactorial immunological mechanism of such reactions.

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Section: Introductionmentioning

confidence: 99%

Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization

Edelman¹,

Malmström

He³

et al. 1999

European Journal of Pediatrics

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“…In this context, the role of early childhood immunisation has been contentious. The findings from epidemiological studies examining immunisation and allergic disease have been inconsistent and varied for different vaccines and settings (10–17). It has been suggested that by preventing natural infection or by providing a different microbial exposure or altering the natural microbial flora, immunisation may contribute to the development of allergic diseases.…”

mentioning

confidence: 99%

Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: A prospective study of allergy-prone children from birth to six years

Thomson

Widjaja

Darmaputra

et al. 2010

Pediatric Allergy and Immunology

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The role of early childhood infections and immunisation in the development of allergic diseases remains controversial. To examine these associations, six hundred and twenty infants with first-degree relatives with allergic diseases were recruited into the Melbourne Atopy Cohort Study. Information on risk factors and outcomes was collected by interviewer administered questionnaire and was based on parental report and/or a physician's diagnosis. Risk factors examined included early childhood infections (including gastroenteritis, otitis media and lower respiratory tract infections) and immunisations in the first 2 yr of life. Outcomes were current asthma, allergic rhinitis and eczema at 6 yr of age. Univariate and multivariate regression analysis were used to estimate relative risk (RR) and assess confounding. By 6 yr, 79% of the original cohort remained in the study. Those with at least three episodes of gastroenteritis showed an increased risk (crude RR 2.36, 95%CI 1.41 3.95; adjusted RR 2.03 95%CI 1.50 2.75) for the later development of asthma at age 6. Of the scheduled immunisations, Sabin immunisation in the second year had a reduced risk of asthma at 6 yr (crude RR 0.60, 95%CI 0.37 0.98; adjusted RR 0.63 95%CI 0.39 1.02). Combined diphtheria and tetanus (CDT) immunisation in the first year had an increased risk of asthma at 6 yr (RR 1.76, 95%CI 1.11 2.78; adjusted RR 1.88 95%CI 1.28 2.77). Recurrent gastroenteritis in early childhood is associated with a later risk of asthma. This may reflect a cause and effect relationship, or exposure to common risk factors. In contrast, Sabin immunisation in the second year is associated with a decreased risk of asthma in later childhood. CDT immunisation in the first year may be a risk factor for asthma, but the need for CDT immunisation may also be a marker of increased risk of asthma in later childhood.

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“…[6][7][8] Some report no association [9][10][11] with atopic disease, whereas others report an increased risk, 12 and some report that it is protective. [13][14][15] Similarly, conflicting evidence has been reported for other vaccines including diphtheria, tetanus and polio.…”

mentioning

confidence: 99%

Is childhood immunisation associated with atopic disease from age 7 to 32 years?

Nakajima

Dharmage

Carlin

et al. 2007

Thorax

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Immunoglobulin E and G responses to pertussis toxin in children immunised with adsorbed and non-adsorbed whole cell pertussis vaccines

Cited by 16 publications

References 15 publications

Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization

Local reactions and IgE antibodies to pertussis toxin after acellular diphtheria-tetanus-pertussis immunization

Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: A prospective study of allergy-prone children from birth to six years

Is childhood immunisation associated with atopic disease from age 7 to 32 years?

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