Immunoglobulin and C₃ abnormalities in acute psychiatric disorders

Abstract

In a prospective study of 54 patients with acute psychiatric disorders, elevated absolute concentrations of immunoglobulin G (IgG), IgM and complement factor C3 were found in the cerebrospinal fluid (CSF) in seven (P less than 0.001), eight (P less than 0.01) and in four patients, respectively, and in serum in seven, 19 and 17 patients (P less than 0.001 in all), respectively, quantified by automated immunoprecipitin nephelometry in unconcentrated CSF and serum and compared with neurological controls with peripheral neurological symptoms. Elevation of the IgG-index was observed in seven patients (P less than 0.001) and CSF/S albumin ratio in four patients (P less than 0.05). The presence of oligoclonal IgG bands was found in 22 patients (P less than 0.001). The results suggest that viral infections, inflammatory and autoimmune processes may have significance in the etiopathogenesis of acute psychiatric disorders.

Haloperidol and lithium carbonate treatment did not influence serum immunoglobulin levels in schizophrenic and affective patients

“…IgM serum levels were in the normal range in schizophrenic patients (10,16,17), and psychiatric patients (lo), increased in psychiatric patients (24), in schizophrenic patients (7), in acute schizophrenic patients (20) and in acute mental disorders (22); reduced in psychiatric patients (1 5), in schizophrenic patients (6,14) and in a small mental disorder group that included mainly depressed patients (8).…”

“…Conflicting findings have been reported in immunoglobulin serum levels in psychiatric patients. Unaltered IgG serum levels were observed in schizophrenic patients (10,12,(15)(16)(17), in psychiatric patients (10,(17)(18)(19), and depressed patients (10); they were decreased in schizophrenic patients (6), and increased in acute schizophrenic patients (20,21), and acute mental disorders (22).…”

İlk Epizod Psikoz Olgularında Serum Neopterin ve Haptoglobulin Düzeyleri

“…plasma concentrations of acute phase proteins or reactants such as haptoglobin (Hp), alpha-acid glycoprotein, alpha-1-antitrypsin, fibrinogen, complement components C3 and C4 and hemopexin, immunoglobulins, cytokines) and substances which are known to induce an acute phase response (e.g. interleukin (IL)-1β, IL-6 and tumor necrosis factor α (TNF-α)) have also been studied in schizophrenia (2,3,4,5,6,7,8,9,10,11,12) Neopterin is a non-specific indicator of cellular immune activation and it is secreted by activated macrophages (13). Plasma and urinary levels of neopterin have been studied in patients with schizophrenia with conflicting results (14,15,16,17,18,19).…”