Immunoglobulin A in the respiratory tract of the chicken following exposure to Newcastle disease virus

Parry, S H; Aitken, I.D.

doi:10.1136/vr.93.9.258

Cited by 33 publications

(16 citation statements)

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“…This may be due to the inverse relationship between vaccinal response and the levels of antibody existing at the time of vaccination as shown when vaccine responses in MI and S chickens are compared, or it may be due to factors not yet determined. The high levels of Ulster virus recovered from the respiratory tract in the 4 days following vaccination, and the marked absence of virus thereafter, implies that the immunological response occurs in the respiratory tract at about this time as suggested previously (Gough and Alexander, 1973;Parry and Aitken, 1973). The excretion of up to 10 2-O EID 5O /g of virus in the faeces for a period of 11 days after infection would indicate that virus is able to replicate in the intestinal tract in the presence of circulating antibodies (Kohn, 1959).…”

Section: Discussionsupporting

confidence: 59%

Aerosol vaccination against Newcastle disease using the Ulster strain

Gough

Allan

1976

Avian Pathology

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Section: Discussionsupporting

confidence: 59%

Aerosol vaccination against Newcastle disease using the Ulster strain

Gough

Allan

1976

Avian Pathology

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“…1 Antibody mean titres (Log 2 X) in experimentally infected, vaccinated/infected and negative control pigeons of Experiment 02 efficient than vaccination via drinking water or feed in free-range chickens (Thekisoe et al 2004), and of high antibody titers in white-tailed eagles after intranasal La Sota vaccine (Bailey et al 1998). Additionally, the ocular route induces local immune response, increasing specific secretory IgA, which is critically important in protection against challenge infections (Parry and Aitken 1973;Takada and Kida 1996).…”

Section: Discussionmentioning

confidence: 99%

Protection levels of vaccinated pigeons (Columba livia) against a highly pathogenic newcastle disease virus strain

Carrasco

Seki

Sousa

et al. 2009

Trop Anim Health Prod

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The purposes of this study were to model a vaccination regimen for Newcastle disease virus (NDV) in pigeons, and to evaluate the susceptibility and behavior of vaccinated birds against a highly pathogenic NDV Brazilian strain. Antibody response was assessed by means of hemagglutination inhibition test (HI), and viral genome excretion by means of RT-PCR. Vaccinal strains (La Sota and Ulster) induced high antibody titers without any adverse effects, both in inoculated and in sentinel birds. A viral strain pathogenic for chickens did not produce clinical signs of the disease in experimentally infected pigeons. Only 4 out of 10 vaccinated pigeons shed NDV genome, and just for two days. Results confirmed the high infectivity of the vaccinal strains used, as all nonvaccinated pigeons showed antibody titers as high as those of vaccinated birds.

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“…Vaccination using nonvirulent NDV strains protects susceptible birds against disease, producing an antibody response either locally, systemically or both. Several stud-Immune response to NDV vaccines www.bjournal.com.br ies have reported that the mucosal application of attenuated live virus induces both systemic and local immunity, while parenteral immunization with inactivated vaccines generally induces systemic immunity (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Locally produced mucosal IgG in chickens immunized with conventional vaccines for Newcastle disease virus

Zoth

Gómez

Carrillo

et al. 2008

Braz J Med Biol Res

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Newcastle disease virus (NDV) is the causative agent of an economically important disease, which affects all species of birds worldwide. Current vaccination programs for NDV include the use of either low-virulent live-virus vaccines or inactivated vaccines to induce protective immunity while producing minimal adverse effects in birds. In order to further characterize the immune response elicited by live virus and inactivated NDV conventional vaccines in chickens, we evaluated the presence of specific antibodies in different secretions and in tissue culture supernatants of immunized birds. To this end, we analyzed all the samples by ELISA, using an indirect assay set up in the laboratory. Specific anti-NDV IgG antibodies were detected in tracheal and cloacal swabs and tracheal and intestinal washes of immunized animals. We also found specific anti-NDV IgG antibodies in tracheal and intestinal tissue culture supernatants, indicating that the IgG found in swabs and washes was not transudated from serum or, at least, was not all transudated from serum. Knowledge about the mechanisms involved in the immune response of chickens to different NDV vaccines should increase our understanding of the mucosal response against the virus and, eventually, provide new useful information for the development and evaluation of synthetic vaccines.

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Immunoglobulin A in the respiratory tract of the chicken following exposure to Newcastle disease virus

Cited by 33 publications

References 0 publications

Aerosol vaccination against Newcastle disease using the Ulster strain

Aerosol vaccination against Newcastle disease using the Ulster strain

Protection levels of vaccinated pigeons (Columba livia) against a highly pathogenic newcastle disease virus strain

Locally produced mucosal IgG in chickens immunized with conventional vaccines for Newcastle disease virus

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