Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

Městecký, Jiří; McGhee, Jerry R.

doi:10.1016/s0065-2776(08)60240-0

Cited by 915 publications

(503 citation statements)

References 477 publications

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“…Mature cells are distributed to the lamina propria underlying mucosal surfaces to produce immunoglobulin (predominately IgA) for transport by the polymeric immunoglobulin receptor (pIgR) to the mucosal surfaces. The mucosal surfaces are linked via this system; exposure to antigen at one mucosal surface provides specific immunity to that antigen at other mucosal sites [14,19,29].…”

Section: Introductionmentioning

confidence: 99%

Parenteral Nutrition Induces Organ Specific Alterations in Polymeric Immunoglobulin Receptor Levels

Sano

Gómez

Hermsen

et al. 2008

Journal of Surgical Research

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Background-Secretory IgA prevents pathogen adherence at mucosal surfaces to prevent infection. Polymeric immunoglobulin receptor (pIgR), located on the basolateral surface of mucosal cells, binds dimeric IgA produced by B cells with the cooperation of T cells in the lamina propria. This IgA-pIgR complex is transported apically, where it is exocytosed as secretory IgA to the mucosal surface. Our prior work shows that parenteral nutrition (PN) impairs both airway and small intestine mucosal immunity by reducing T & B cells and IgA levels. This work examines intestinal and respiratory tissue-specific pIgR responses to PN.

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Section: Introductionmentioning

confidence: 99%

Parenteral Nutrition Induces Organ Specific Alterations in Polymeric Immunoglobulin Receptor Levels

Sano

Gómez

Hermsen

et al. 2008

Journal of Surgical Research

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“…The mucosal immune system is responsible of 60% of the daily production of immunoglobulins (Mestecky & McGhee, 1987); however, the experimental induction of immune response at intestinal level has proven difficult. The cytokines released by the associated immune cells, may favour either a Th1 immunogenic response, a Th2 humoral or tolerogenic, or only an inflammatory response (Gonnella et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Interaction of lactic acid bacteria with the gut immune system

et al. 2002

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Health claims of lactic acid bacteria (LAB) used in functional foods and pharmaceutical preparations are based on the capacity of these microorganisms to stimulate the host immune system. In this study, the antigenic effect of LAB (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) on the gut immune system of BALB=c mice was evaluated. A dose-dependent increase of the Bcl2 protein was observed with all LAB assayed. Furthermore, the analysis of cytokine-producing cells in the lamina propria of gut showed that TNFa and INFg values, determined in macrophages cultured from Peyer patches, were enhanced for all the LAB assayed. An important increase of interleukins IL-10 and IL-4 was observed mainly in mice fed with Lactobacillus delbrueckii ssp. bulgaricus or Lactobacillus casei, while a significant induction of IL-2 and IL-12 was only observed with L. acidophilus (P < 0.01). These effects were dose dependent. The role of produced cytokines in the balance Th1=Th2 was determined by a systemic antibody response against parenterally injected ovoalbumin. L. casei, L. delbrueckii ssp. bulgaricus and L. acidophilus enhanced the IgG1 response favouring Th2 balance, while L. acidophilus also increased the IgG2a response inducing Th1 balance. S. thermophilus did not influence the balance Th1=Th2. Our studies showed that lactic acid bacteria induce distinct mucosal cytokine profiles showing different adjuvant capacity among them. Thus, selection of probiotic strain with immunological properties must be well defined to influence cytokine expression that favour the claimed immune response.

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“…Therefore, the assembled molecule of secreted IgA is the product of two entirely different cell types: plasma cells and epithelial cells. 17 …”

Section: Discussionmentioning

confidence: 99%

Pathogenesis of IgA nephropathy: A Review

Akash

2006

Dial. Transplant.

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Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

Cited by 915 publications

References 477 publications

Parenteral Nutrition Induces Organ Specific Alterations in Polymeric Immunoglobulin Receptor Levels

Parenteral Nutrition Induces Organ Specific Alterations in Polymeric Immunoglobulin Receptor Levels

Interaction of lactic acid bacteria with the gut immune system

Pathogenesis of IgA nephropathy: A Review

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