Immunogenicity of umbilical cord tissue–derived cells

Cho, Patricia S.; Messina, Darin J.; Hirsh, Erica L.; Chi, Nina; Goldman, Stephanie N.; Lo, Diana P.; Harris, Ian R.; Popma, Sicco H.; Sachs, David H.; Huang, Christene A.

doi:10.1182/blood-2007-03-078774

Cited by 207 publications

(187 citation statements)

References 30 publications

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“…Even if these cells do not present HLA antigens, other histocompatibility tests must be performed in an attempt to prove whether the EPCs differentiated in vitro trigger an allogeneic immune response. In a study with mesenchymal cells, Cho et al [25] described that allogeneic mesenchymal cells do not trigger an immune response in normal tissue, but in regions of inflammation; i.e., in the presence of cytokines such as IFN-ã-, where rejection can occur. Based on this information, there may be a more solid basis to make viable the use of the differentiated EPCs derived from HUCBs in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Formação in vitro de túbulos capilares a partir de células de sangue de cordão umbilical humano com perspectivas para aplicação terapêutica

Senegaglia¹,

Brofman²,

Aita³

et al. 2008

Rev Bras Cir Cardiovasc

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ResumoObjetivo: As células progenitoras endoteliais (CPE), caracterizadas pelo marcador CD133+, contribuem para a neovascularização, e o aumento no número dessas células pode ser uma ferramenta terapêutica promissora. O sangue de cordão umbilical humano contém um número significante de CPE, sugerindo a possibilidade do uso destas células para a revascularização de tecidos isquêmicos. O objetivo desse trabalho foi analisar a funcionalidade das células CD133+ diferenciadas in vitro.Métodos: As células diferenciadas foram caracterizadas 468SENEGAGLIA, AC ET AL -In vitro formation of capillary tubules from human umbilical cord blood cells with perspectives for therapeutic application Bras Cir Cardiovasc 2008; 23(4): 467-473 Rev

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Section: Discussionmentioning

confidence: 99%

Formação in vitro de túbulos capilares a partir de células de sangue de cordão umbilical humano com perspectivas para aplicação terapêutica

Senegaglia¹,

Brofman²,

Aita³

et al. 2008

Rev Bras Cir Cardiovasc

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“…Beyond their multilineage potential, MSCs came into prominence as a highly immunosuppressive cell population exhibiting extensive immunomodulatory properties that are independent of histocompatibility (3). As MSCs do not express MHC class II or costimulatory molecules, a single injection of MSCs does not appear to elicit a strong immune response (4,5). In addition, clinical experience indicates that MSC administration is safe and can promote hematopoietic engraftment and tissue repair (3).…”

mentioning

confidence: 99%

Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells

Mathias

Khong

Spyroglou

et al. 2013

The Journal of Immunology

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Multipotent mesenchymal stromal cells (MSCs) possess reparative and immunoregulatory properties, making them attractive candidates for cellular therapy. However, the majority of MSCs administered i.v. encounter a pulmonary impasse and soon disappear from the lungs, raising the question of how they induce such durable immunosuppressive effects. Using a mouse model of allergic asthma, we show that administration of MSCs isolated from human bone marrow, umbilical cord, or adipose tissue provoked a pronounced increase in alveolar macrophages and inhibited hallmark features of asthma, including airway hyperresponsiveness, eosinophilic accumulation, and Th2 cytokine production. Importantly, selective depletion of this macrophage compartment reversed the therapeutic benefit of MSC treatment on airway hyperresponsiveness. Our data demonstrate that human MSCs exert cross-species immunosuppressive activity, which is mediated by alveolar macrophages in allergic asthma. As alveolar macrophages are the predominant immune effector cells at the air–tissue interface in the lungs, this study provides a compelling mechanism for durable MSC effects in the absence of sustained engraftment.

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“…Moreover, the extracorporeal nature of this source facilitates isolation by eliminating invasive procedures and patient discomfort [16]. These mesenchymal cells are potentially quite applicable to human patients without a complete genetic match since they are unlikely to induce an acute inflammatory response [17].…”

Section: Treatment Of Hep-2 Cell Line With Wharton's Jelly Mesenchymamentioning

confidence: 99%

The Effect of Wharton's Jelly Mesenchymal Stem Cells on a Squamous Cell Carcinoma Cell Line

Elias¹

2016

Arch Can Res

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Background: Wharton's jelly mesenchymal stem cells may be more useful for cancer therapy than other adult stem cells since they are easily prepared in relatively large quantities from the umbilical cord after delivery. This study aims to determine the anticancer effect of WJMSC-conditioned medium on a HEP-2 cell line after 24, 48, and 72 hours using flow cytometry and real-time polymerase chain reaction.

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Immunogenicity of umbilical cord tissue–derived cells

Cited by 207 publications

References 30 publications

Formação in vitro de túbulos capilares a partir de células de sangue de cordão umbilical humano com perspectivas para aplicação terapêutica

Formação in vitro de túbulos capilares a partir de células de sangue de cordão umbilical humano com perspectivas para aplicação terapêutica

Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells

The Effect of Wharton's Jelly Mesenchymal Stem Cells on a Squamous Cell Carcinoma Cell Line

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