Immunogenicity of a Recombinant Hepatitis B Vaccine in Adults

Bock, Hans L.; Kruppenbacher, J. P.; Sänger, Roland; Höbel, Wilfried; Clemens, Ralf; Jilg, Wolfgang

doi:10.1001/archinte.1996.00440180088011

Cited by 53 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additional studies with mice have documented gender-dependent differences in response to keyhole limpet hemocyanin (67), OVA (67), hen egg lysozyme (20), and polyvinyl pyrrolidone (13), with female mice mounting more potent antigen-specific immune responses than males. Similar gender-dependent differences in vaccinated swine and humans have been reported (3,8,48). Importantly, an HSV experimental vaccine was protective in human females but not in males (60), and a pseudorabies virus vaccine resulted in significantly lower virus excretion in female swine than in male swine (8).…”

Section: Discussionsupporting

confidence: 61%

“…Because gender differences in response to vaccines have been reported, (3,8,13,20,48,64,67), we examined these three best immunization strategies, DNA prime-rMVA boost, peptide prime-rMVA boost and rMVA prime-rMVA boost for their ability to induce antigen-specific T-cell responses in spleens of both female and male BALB/c mice (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…First, the age of the vaccinee may affect the response. There were no differences in postimmunization vaccine-specific antibody titers between genders in infants vaccinated with acellular or whole-cell pertussis vaccines (6), while vaccination of adult females resulted in antigen-specific immune responses significantly greater than those induced in adult males (3,48,60). In contrast, with the inactivated influenza vaccine, there was no significant difference in vaccine-specific immune responses between adult men and women (2,6).…”

Section: Discussionmentioning

confidence: 99%

“…Gender has also been reported to affect immune responses after pseudorabies virus vaccination of swine (8). Vaccine-induced antibody responses were significantly greater in women than men (3,48), and a herpes simplex virus (HSV) vaccine was protective in females but not in males (60). Measurement of antigen-specific immune responses by enzyme-linked immunosorbent assay, neutralizing antibody, lymphocyte proliferation, and gamma interferon IFN-␥ secretion assays in the HSV vaccine trial did not reveal any differences in the magnitude of vaccine-induced immunity between males and females, although significant differences in efficacy were observed (60).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Peacock¹,

Nordone²,

Jackson

et al. 2004

J Virol

View full text Add to dashboard Cite

Induction of mucosal anti-human immunodeficiency virus type 1 (HIV-1) T-cell responses in males andfemales will be important for the development of a successful HIV-1 vaccine. An HIV-1 envelope peptide, DNA plasmid, and recombinant modified vaccinia virus Ankara (rMVA) expressing the H-2D d -restricted cytotoxic T lymphocyte P18 epitope were used as immunogens to test for their ability to prime and boost anti-HIV-1 T-cell responses at mucosal and systemic sites in BALB/c mice. We found of all prime-boost combinations tested, an HIV-1 Env peptide subunit mucosal prime followed by systemic (intradermal) boosting with rMVA yielded the maximal induction of gamma interferon (IFN-␥) spot-forming cells in the female genital tract and colon. However, this mucosal prime-systemic rMVA boost regimen was minimally immunogenic for the induction of genital, colon, or lung anti-HIV-1 T-cell responses in male mice. We determined that a mucosal Env subunit immunization could optimally prime an rMVA boost in female but not male mice, as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tracts, colon, and lung. Defective mucosal priming in male mice could not be overcome by multiple mucosal immunizations. However, rMVA priming followed by an rMVA boost was the optimal prime-boost strategy for male mice as determined by the magnitude of antigen-specific IFN-␥ responses in the reproductive tract and lung. Thus, prime-boost immunization strategies able to induce mucosal antigen-specific IFN-␥ responses were identified for male and female mice. Understanding the cellular and molecular basis of gender-determined immune responses will be important for optimizing induction of anti-HIV-1 mucosal immune responses in both males and females.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Peacock¹,

Nordone²,

Jackson

et al. 2004

J Virol

View full text Add to dashboard Cite

show abstract

“…Because the number of hepatitis B nonresponders is significant and protection is of crucial importance for risk populations such as health care professionals, this specific type of vaccination failure has been investigated in more detail. Risk factors such as obesity, heavy smoking, or renal disease have been determined (4,5), and, additionally, certain HLA class II subtypes (HLA-DRB1, HLA-DQB1) have been associated with nonresponsiveness to current hepatitis B vaccines (6). Also, the role of IL-10 in hepatitis B nonresponsiveness has been highlighted in several studies.…”

mentioning

confidence: 99%

Tick-Borne Encephalitis (TBE) and Hepatitis B Nonresponders Feature Different Immunologic Mechanisms in Response to TBE and Influenza Vaccination with Involvement of Regulatory T and B Cells and IL-10

Garner-Spitzer

Wagner

Paulke‐Korinek

et al. 2013

The Journal of Immunology

View full text Add to dashboard Cite

Low responsiveness/nonresponsiveness is characterized by an insufficient immune response upon primary and/or booster vaccination and affects 1–10% of vaccinees. In the current study, we aimed to investigate whether nonresponsiveness is an Ag/vaccine-specific phenomenon and to clarify underlying immunological mechanisms. Nonresponders to tick-borne encephalitis (TBE) or hepatitis B Ag with a history of previous TBE vaccinations were booster vaccinated with TBE and influenza vaccine and compared with TBE high responders in terms of humoral and cellular immune response. Postboosters in TBE high responder existing TBE titers increased, and solid humoral responses to influenza vaccine were induced. In TBE nonresponders, low to undetectable prevaccination TBE titers remained low, whereas sufficient influenza Abs were induced. In both TBE groups, a positive correlation of humoral and cellular immune response was seen as high/low TBE titers were associated with sufficient/lack of Ag-specific T cell proliferation. Furthermore, responses to influenza were robust in terms of Abs and cytokine production. In contrast, in hepatitis B nonresponders, sufficient humoral responses to TBE and influenza Ags were induced despite lacking specific IL-2 and IFN-γ production. Importantly, these patients showed high IL-10 baseline levels in vitro. HLA-DR subtypes associated with hepatitis B nonresponsiveness were overrepresented in this group, and high IL-10 levels were linked to these subtypes. Whereas TBE and hepatitis B nonresponders had increased IL-10–producing FOXP3+ T regulatory cells upon vaccination, only in hepatitis B nonresponders, showing elevated prevaccination IL-10 levels, a prominent population of B regulatory cells was detected. We conclude that immunological pathways of nonresponsiveness follow different patterns depending both on vaccine Ag and genetic predisposition of the vaccinee.

show abstract

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

2012

View full text Add to dashboard Cite

Summary The intensity and prevalence of viral infections are typically higher in males, whereas disease outcome can be worse for females. Females mount higher innate and adaptive immune responses than males, which can result in faster clearance of viruses, but also contributes to increased development of immunopathology. In response to viral vaccines, females mount higher antibody responses and experience more adverse reactions than males. The efficacy of antiviral drugs at reducing viral load differs between the sexes, and the adverse reactions to antiviral drugs are typically greater in females than males. Several variables should be considered when evaluating male/female differences in responses to viral infection and treatment: these include hormones, genes, and gender-specific factors related to access to, and compliance with, treatment. Knowledge that the sexes differ in their responses to viruses and to treatments for viral diseases should influence the recommended course of action differently for males and females.

show abstract

Immunogenicity of a Recombinant Hepatitis B Vaccine in Adults

Abstract: The large immune response that was elicited by this hepatitis B vaccine in adults under daily routine field conditions reflected reality, with a high SPR also found in elderly and other persons with risk factors associated with a lower immune response.

Cited by 53 publications

References 19 publications

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Tick-Borne Encephalitis (TBE) and Hepatitis B Nonresponders Feature Different Immunologic Mechanisms in Response to TBE and Influenza Vaccination with Involvement of Regulatory T and B Cells and IL-10

Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases

Contact Info

Product

Resources

About