Immunogenicity of a modified-live virus vaccine against bovine viral diarrhea virus types 1 and 2, infectious bovine rhinotracheitis virus, bovine parainfluenza-3 virus, and bovine respiratory syncytial virus when administered intranasally in young calves

Xue, Wei; Ellis, John; Mattick, Debra; Smith, Linda; Brady, Ryan P; Trigo, E

doi:10.1016/j.vaccine.2010.03.043

Cited by 39 publications

(32 citation statements)

References 11 publications

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“…To overcome this issue, research in recent years has focused on the use of the mucosal immune system for vaccination. Intranasal vaccination against BRSV proved effective in challenge studies in calves without maternal antibodies [104][105][106][107]. In calves with maternal antibodies against BRSV, protective effect of intranasal vaccination compared to an unvaccinated control group was confirmed in two studies [106,108].…”

Section: Specific Prevention (Vaccination)mentioning

confidence: 91%

“…Vaccination of newborn calves, especially in the presence of maternal antibodies, poses the same challenges as described for BRSV vaccination and is in the focus of current research [111]. Intranasal vaccination of seronegative newborn calves decreases clinical signs in a challenge trial [107]. However, the situation is complicated by the potential for establishment of seronegative latent carriers in calves with specific maternal antibodies through field virus infection as well as through vaccination with modified-live vaccines [112,113].…”

Section: Specific Prevention (Vaccination)mentioning

confidence: 99%

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Calf health from birth to weaning. III. housing and management of calf pneumonia

Lorenz

Earley

Gilmore³

et al. 2011

Ir Vet J

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Calfhood diseases have a major impact on the economic viability of cattle operations. A three part review series has been developed focusing on calf health from birth to weaning. In this paper, the last of the three part series, we review disease prevention and management with particular reference to pneumonia, focusing primarily on the pre-weaned calf. Pneumonia in recently weaned suckler calves is also considered, where the key risk factors are related to the time of weaning. Weaning of the suckler calf is often combined with additional stressors including a change in nutrition, environmental change, transport and painful husbandry procedures (castration, dehorning). The reduction of the cumulative effects of these multiple stressors around the time of weaning together with vaccination programmes (preconditioning) can reduce subsequent morbidity and mortality in the feedlot. In most studies, calves housed individually and calves housed outdoors with shelter, are associated with decreased risk of disease. Even though it poses greater management challenges, successful group housing of calves is possible. Special emphasis should be given to equal age groups and to keeping groups stable once they are formed. The management of pneumonia in calves is reliant on a sound understanding of aetiology, relevant risk factors, and of effective approaches to diagnosis and treatment. Early signs of pneumonia include increased respiratory rate and fever, followed by depression. The single most important factor determining the success of therapy in calves with pneumonia is early onset of treatment, and subsequent adequate duration of treatment. The efficacy and economical viability of vaccination against respiratory disease in calves remains unclear.

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Section: Specific Prevention (Vaccination)mentioning

confidence: 91%

Section: Specific Prevention (Vaccination)mentioning

confidence: 99%

Calf health from birth to weaning. III. housing and management of calf pneumonia

Lorenz

Earley

Gilmore³

et al. 2011

Ir Vet J

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show abstract

“…Virus neutralizing antibody titers against BToV in paired sera from affected cows were measured using HRT-18 cells and the BToV strain Aichi/2004 [16]. Virus neutralization (VN) tests were also conducted for bovine viral diarrhea (BVDV) type 1, bovine adenovirus type 3 (BAdV-3), bovine herpesvirus 1 (BHV-1), and bovine respiratory syncytial virus (BRSV) as described previously [36]. Antibody titers against BCV, adenovirus type 7 (BAdV-7), and bovine parainfluenza virus type 3 (BPIV-3) were determined by hemagglutination inhibition (HI) tests [20].…”

Section: Virus-neutralization and Hemagglutination Inhibition Testsmentioning

confidence: 99%

Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows

et al. 2011

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Bovine torovirus (BToV) is recognized as an enteric pathogen of calves, but its etiological role in diarrhea and epidemiological characterization in adult cows remain unclear. In 2007-2008, three outbreaks of epidemic diarrhea occurred in adult cows at three dairy farms in Niigata Prefecture, Japan. BToV was the only enteric pathogen detected in these outbreaks, as determined by electron microscopy, reverse transcription-PCR, bacteria and parasite tests of fecal samples, and antibody tests with paired sera. The epidemiological features of the three outbreaks were similar to those of bovine coronavirus infection, except for the absence of bloody diarrhea, with diarrhea spreading among most adult cows, but not in calves, within several days and diarrhea lasting for 3-5 days with anorexia. Decreased milk production and mild respiratory symptoms were also observed in two of the outbreaks. Nucleotide sequence analysis of the BToV nucleocapsid, spike, and hemagglutinin-esterase (HE) genes revealed a close relatedness among the detected BToV strains from each outbreak and those of Japanese BToV strain Aichi/2004. Furthermore, we isolated a BToV strain, designated Niigata (TC), from a fecal sample using a human rectal tumor cell line. Sequence analysis of this isolate and Aichi/2004 indicated that both strains have truncated HE genes with deletions in the 3' region that occurred through cell culture-adaptation. The short projections that are believed to be formed by the HE protein on virus particles were not observed in these cultured strains by electron microscopy. Taken together, these results suggest that BToV causes epidemic diarrhea in adult cows and should be included in the differential diagnosis of diarrhea in adult cows. In addition, our findings indicate that the HE protein of BToV may not be necessary for viral replication.

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“…Because of the similarities between HRSV and BRSV, it should be possible to gain insight regarding factors that impact safety, efficacy, and duration of immunity in individuals vaccinated either in the presence or absence of circulating neutralizing antibodies using the BRSV model. Many published studies have shown that commercially available BRSV vaccines can induce protection against experimentally induced or naturally occurring BRSV disease (Durham and Hassard, 1990;Ellis et al, 2001;Van Donkersgoed et al, 1990b;Vangeel et al, 2007b;Verhoeff and van Nieuwstadt, 1984;West et al, 1999b;Xue et al, 2010).…”

Section: Vaccines For Brsvmentioning

confidence: 99%

“…Although BRSV vaccine ERD has been well-studied, extensive research and clinical experience indicate that BRSV vaccination can be safe and effective (Ellis et al, 1995;Ellis et al, 2005;Van Donkersgoed et al, 1990a;Vangeel et al, 2007a;Vangeel et al, 2009;Verhoeff and van Nieuwstadt, 1984;West et al, 1999b;Xue et al, 2010). In studies of resistance to experimental challenge, vaccination of calves with low or absent concentrations of serum neutralizing antibodies can protect them from virulent challenge.…”

Section: Vaccines For Brsvmentioning

confidence: 99%

Animal Models of Respiratory Syncytial Virus Pathogenesis and Vaccine Development: Opportunities and Future Directions

Woolums¹,

Moore²

2011

Human Respiratory Syncytial Virus Infection

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Immunogenicity of a modified-live virus vaccine against bovine viral diarrhea virus types 1 and 2, infectious bovine rhinotracheitis virus, bovine parainfluenza-3 virus, and bovine respiratory syncytial virus when administered intranasally in young calves

Cited by 39 publications

References 11 publications

Calf health from birth to weaning. III. housing and management of calf pneumonia

Calf health from birth to weaning. III. housing and management of calf pneumonia

Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows

Animal Models of Respiratory Syncytial Virus Pathogenesis and Vaccine Development: Opportunities and Future Directions

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