Immunogenicity and reactogenicity following MMR vaccination in 5–7-month-old infants: a double-blind placebo-controlled randomized clinical trial in 6540 Danish infants

Vittrup, Dorthe Maria; Jensen, Andreas; Sørensen, Jesper Kiehn; Zimakoff, Anne Cathrine; Malon, Michelle; Charabi, Salma; Johansen, Marie Ryberg; Simões, Eric A.F.; Kirkby, Nikolai Søren; Buus, Søren; Svensson, Jannet; Stensballe, Lone Graff

doi:10.1016/j.eclinm.2023.102421

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eClinicalMedicine

2024

DOI: 10.1016/j.eclinm.2023.102421

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Immunogenicity and reactogenicity following MMR vaccination in 5–7-month-old infants: a double-blind placebo-controlled randomized clinical trial in 6540 Danish infants

Dorthe Maria Vittrup,

Andreas Jensen,

Jesper Kiehn Sørensen

et al.

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2024

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Cited by 3 publications

References 28 publications

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Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Kemme,

Canniff,

Garth

et al. 2024

American Journal of Transplantation

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Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Kemme,

Canniff,

Garth

et al. 2024

American Journal of Transplantation

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Comparison of measles plaque reduction neutralization test (PRNT) and measles virus-specific IgG ELISA for assessment of immunogenicity of measles-mumps-rubella vaccination at 5–7 months of age and maternal measles antibodies

Vittrup,

Jensen,

Malon

et al. 2024

Vaccine: X

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The effect of stress on the antibody response after vaccination in children aged 0–18 years: A systematic review

Svensson,

Malon,

Stensballe

et al. 2024

Scand J Immunol

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Stress has been associated with less effective vaccine responses in adults. This review aims to investigate the evidence for a similar association in children. A systematic review search was conducted in January 2021 in three databases: Medline, Embase and PsycInfo. An updated search of the Medline database was systematically conducted until the most recent update on September 25th, 2023, to ensure the inclusion of the most current research available. Keywords related to stress, vaccines and children were used, and a total of 7263 (+1528) studies were screened by two independent investigators. Six studies met the inclusion criteria for data extraction and analysis. For quality assessment of the studies, the risk of bias in non‐randomized studies—of interventions (ROBINS‐I) tool was applied. Most of the studies suggest a negative role of stress on vaccine responses. However, the scarcity of studies, lack of confirmatory studies, risk of bias and heterogeneity according to age, type of vaccine, measures of stress and vaccine responses prevent a clear conclusion. Future studies should emphasize the use of as strict study designs as possible, including well‐defined stress metrics and thorough examination of both pre‐ and post‐vaccination responses. Systematic review registration: Prospero CRD42021230490.

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Immunogenicity and reactogenicity following MMR vaccination in 5–7-month-old infants: a double-blind placebo-controlled randomized clinical trial in 6540 Danish infants

Cited by 3 publications

References 28 publications

Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

Comparison of measles plaque reduction neutralization test (PRNT) and measles virus-specific IgG ELISA for assessment of immunogenicity of measles-mumps-rubella vaccination at 5–7 months of age and maternal measles antibodies

The effect of stress on the antibody response after vaccination in children aged 0–18 years: A systematic review

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