Immunogenicity and protective efficacy of inactivated coxsackievirus B4 viral particles
Tingfeng Wang,
Chiyuan Wang,
Lili Pang
et al.
Abstract:Coxsackievirus B4 (CVB4) is associated with a range of acute and chronic diseases such as hand, foot, and mouth disease, myocarditis, meningitis, pancreatitis, and type 1 diabetes, affecting millions of young children annually around the world. However, no vaccine is currently available for preventing CVB4 infection. Here, we report the development of inactivated viral particle vaccines for CVB4. Two types of inactivated CVB4 particles were prepared from CVB4-infected cell cultures as vaccine antigens, includi… Show more
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