Immunogenicity and persistence of trivalent measles, mumps, and rubella vaccines: a systematic review and meta-analysis

Schenk, Julie; Abrams, Steven; Theeten, Heidi; Damme, Pierre Van; Beutels, Philippe; Hens, Niel

doi:10.1016/s1473-3099(20)30442-4

Cited by 36 publications

(29 citation statements)

References 53 publications

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“…Both risk groups are considered for anti-rubella catch-up vaccination strategies by STIKO. Lower levels of anti-rubella IgG in response to the introduction of vaccination as well as waning immunity have been observed before [32] , [33] , [34] , [35] , [36] , [37] . Still, antibodies of high avidity most probably provide excellent protection even if present in only low amounts.…”

Section: Discussionmentioning

confidence: 88%

“…Several studies observed lower anti-measles IgG titres and waning humoral immunity after vaccination in contrast to natural measles infections before [32] , [33] , [34] , [35] , [36] , [37] . Vaccinated individuals whose titres are classified as equivocal or negative often have sufficient anti-measles antibodies with neutralizing capacity [23] .…”

Section: Discussionmentioning

confidence: 99%

“…Similar to what has been noted before, we found lower GMTs in response to vaccination [42] . This in combination with waning immunity and the observed low seroprevalence may be an explanation for the observed outbreaks [ 32 , 34 , 37 ]. Regional clusters of insufficiently vaccinated individuals may additionally facilitate mumps outbreaks [43] .…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, cell-derived immunity adds to the protection against the diseases which was also not detected by the approach used in this study [63] . Thus, consideration of seroprevalence only will result in an underestimation of population immunity [ 32 , 34 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Measles-, Mumps-, and Rubella-specific antibodies in the German adult population – cross-sectional analysis of the German Health Interview and Examination Survey for Adults (DEGS1)

Friedrich

Poethko‐Müller

Kuhnert

et al. 2021

The Lancet Regional Health - Europe

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Background The WHO European Region targets the elimination of measles, rubella, and the congenital rubella syndrome and welcomes mumps elimination via the joint MMR vaccine. In a push towards this elimination goal, Germany introduced a recommendation on MMR vaccination for adults in 2010 to prevent increasing numbers of measles cases among adults and to strengthen herd immunity. Methods The prevalence of anti-measles, -mumps, and -rubella IgG antibodies was analysed in 7,115 participants between the ages of 18 and 79 years in the German Health Interview and Examination Survey. Risk factors of seronegativity of adults born 1970 or later were determined. Findings The seroprevalence of anti-measles IgG antibodies was more than 97% in adults born before 1965 and less than 90% in adults born afterwards. Prevalence and GMTs declined with later years of birth. Seronegativity was associated with two-sided migration background and region of residence in East Germany. For anti-mumps IgG antibodies, the seroprevalence was less than 90% in almost all age groups. Prevalence and GMTs declined with later years of birth. Seronegativity was not associated with any socio-demographic factor. Anti-rubella IgG seropositivity was found in more than 90% of adults born before 1985. GMTs declined in younger age groups. Seronegativity was associated with birth between 1980 and 1993 and male gender. High socio-economic status lowered the odds of being seronegative. Interpretation These data reinforce the implementation of the vaccination recommendation for adults and provide the basis for further evaluation of this measure. Funding The Federal Ministry of Health, Germany.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Seroprevalence of Measles-, Mumps-, and Rubella-specific antibodies in the German adult population – cross-sectional analysis of the German Health Interview and Examination Survey for Adults (DEGS1)

Friedrich

Poethko‐Müller

Kuhnert

et al. 2021

The Lancet Regional Health - Europe

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“…Measles can be prevented with an effective live viral vaccine, which is given as a two-dose schedule in routine immunisation programmes in many countries. The seroconversion rate after two doses of the vaccine is around 96%, but there is a slow decline in seroprotection even in healthy children [11]. A greater degree of reduced immunity against measles has been documented in children with malignancies, kidney transplantation, and HIV infection [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Seroprotection against measles in previously vaccinated children with difficult-to-treat nephrotic syndrome

et al. 2021

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Background Children with nephrotic syndrome (NS) are vulnerable to infections. Measles infection is an important cause of morbidity and mortality in immunosuppressed children. A suboptimal seroprotection against measles has been shown in immunocompromised children. There is limited published literature on measles immunity in children with difficult-totreat nephrotic syndrome (DTNS). We compared the proportions of children with DTNS and healthy controls who were seroprotected against measles. Methods This was a cross-sectional study. Measles-specific IgG antibodies of 108 children with DTNS (3 to 10 years of age) and an equal number of age-matched healthy controls were measured. All children had received two doses of measlescontaining vaccine at 9-12 and 16-24 months of age under routine immunisation programme. Serum measles IgG antibody titres were measured by indirect ELISA. The assay results were interpreted as (1) > 11 NTU (NovaTec Units), positive/seroprotective titres; (2) 9-11, equivocal; and (3) < 9 NTU, negative. Inter-and intra-group comparisons were made to identify the disease characteristics related to seroprotection status. ResultsThe proportion of children with protective anti-measles antibodies (n = 70, 65%) was significantly lower in DTNS as compared to controls (n = 88, 81.48%) (p = 0.005). Their median [IQR] antibody titres were also significantly lower than those in controls (14.1 [14] NTU vs. 18.3 [15.2] NTU (p = 0.001). The age, gender, clinical subtype, duration of disease, and type of immunosuppressive therapy were not significantly different between seroprotected and non-seroprotected children with DTNS. Conclusion A significantly lower percentage of fully vaccinated children with DTNS were seroprotected against measles compared to healthy controls.

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Bof/parotitis epidemica

Vries¹

2021

Kleine Kwalen Bij Kinderen

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Immunogenicity and persistence of trivalent measles, mumps, and rubella vaccines: a systematic review and meta-analysis

Cited by 36 publications

References 53 publications

Seroprevalence of Measles-, Mumps-, and Rubella-specific antibodies in the German adult population – cross-sectional analysis of the German Health Interview and Examination Survey for Adults (DEGS1)

Seroprevalence of Measles-, Mumps-, and Rubella-specific antibodies in the German adult population – cross-sectional analysis of the German Health Interview and Examination Survey for Adults (DEGS1)

Seroprotection against measles in previously vaccinated children with difficult-to-treat nephrotic syndrome

Bof/parotitis epidemica

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