Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy

Hernández-Granados, Alex Jesús; Franco‐Molina, Moises Armides; Coronado‐Cerda, Erika Evangelina; Zapata‐Benavides, Pablo; Gamboa, Edgar Mendoza; Ramos-Zayas, Yareellys; Santana-Krímskaya, Silvia Elena; Rodríguez‐Padilla, Cristina

doi:10.1016/j.rvsc.2018.10.001

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Heat shock can induce apoptosis (41−43 °C) or necrosis (>43 °C). [ 202 ] The mechanism underlying the enhanced immunogenicity of tumor cell lysates under heat shock is the production of heat shock proteins (HSPs). When tumor cells are exposed to high temperatures, they are thermally stimulated to produce HSPs to protect themselves.…”

Section: Cancer Vaccines Based On Tumor Cell Lysatementioning

confidence: 99%

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Diao

Liu

2023

Advanced Science

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Cancer immunotherapies have improved human health, and one among the important technologies for cancer immunotherapy is cancer vaccine. Antigens are the most important components in cancer vaccines. Generally, antigens in cancer vaccines can be divided into two categories: pre-defined antigens and unidentified antigens. Although, cancer vaccines loaded with predefined antigens are commonly used, cancer vaccine loaded with mixed unidentified antigens, especially whole cancer cells or cancer cell lysates, is a very promising approach, and such vaccine can obviate some limitations in cancer vaccines. Their advantages include, but are not limited to, the inclusion of pan-spectra (all or most kinds of ) antigens, inducing pan-clones specific T cells, and overcoming the heterogeneity of cancer cells. In this review, the recent advances in cancer vaccines based on whole-tumor antigens, either based on whole cancer cells or whole cancer cell lysates, are summarized. In terms of whole cancer cell lysates, the focus is on applying whole water-soluble cell lysates as antigens. Recently, utilizing the whole cancer cell lysates as antigens in cancer vaccines has become feasible. Considering that pre-determined antigen-based cancer vaccines (mainly peptide-based or mRNA-based) have various limitations, developing cancer vaccines based on whole-tumor antigens is a promising alternative.

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Section: Cancer Vaccines Based On Tumor Cell Lysatementioning

confidence: 99%

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Diao

Liu

2023

Advanced Science

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“…176 Therefore, Dex was engineered to express several cytokines as well; For example, DCs were loaded with adeno-associated virus carrying the AFP gene, which elicited specific CTL responses and antitumor effects against HCC. 177…”

Section: Engineered Evsmentioning

confidence: 99%

“…Dex contains MHCs, costimulatory molecules, adhesion proteins, and several cytosolic factors, contributing to specific targeting and immune responses 176 . Therefore, Dex was engineered to express several cytokines as well; For example, DCs were loaded with adeno‐associated virus carrying the AFP gene, which elicited specific CTL responses and antitumor effects against HCC 177 …”

Section: Genetically Modified Ev Vaccinesmentioning

confidence: 99%

Genetically modified cancer vaccines: Current status and future prospects

Zhou

Zhao

et al. 2022

Medicinal Research Reviews

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Vaccines can stimulate the immune system to protect individuals from infectious diseases. Moreover, vaccines have also been applied to the prevention and treatment of cancers. Due to advances in genetic engineering technology, cancer vaccines could be genetically modified to increase antitumor efficacy. Various genes could be inserted into cells to boost the immune response, such as cytokines, T cell costimulatory molecules, tumor‐associated antigens, and tumor‐specific antigens. Genetically modified cancer vaccines utilize innate and adaptive immune responses to induce durable antineoplastic capacity and prevent the recurrence. This review will discuss the major approaches used to develop genetically modified cancer vaccines and explore recent advances to increase the understanding of engineered cancer vaccines.

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“…Las células tumorales presentan un crecimiento muy rápido, lo que da lugar a una masa tumoral importante y a una gran destrucción de los tejidos locales (9). El TVT se transmite como aloinjerto, principalmente durante el coito (10,11), aunque también puede transmitirse por mordedura, olfateo y lamido de laceración; así, también puede encontrarse en la piel de la cara, las fosas nasales, la cavidad oral y el interior/alrededor de los ojos; ocasionalmente, se ha encontrado en el bazo, el hígado, el cerebro y los pulmones de perros infectados, lo que indica su capacidad de metástasis (9,12).…”

Section: Introductionunclassified

Prevalence and distribution of transmissible venereal tumor in dogs from a rural community of Mexico

et al. 2024

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Objetivo: Determinar la tasa de prevalencia y recurrencia de infección por TVT en perros con propietario y la distribución de la enfermedad en Cuajinicuilapa, Guerrero, México. Métodos: Estudio observacional, descriptivo y longitudinal. Se investigó la presencia de TVT en todos los perros de la comunidad con base en la historia clínica, examen físico y evaluación citológica, y el diagnóstico se confirmó por histopatología. Se retiraron quirúrgicamente muestras de tejido para análisis histopatológico y, cuando se requirió, para eliminar los tumores y tratar con vincristina; se identificaron posibles agrupaciones espaciales por GPS. Todos los casos se reevaluaron un año después. Resultados: Se encontró una prevalencia de 5.15% en 1047 perros (512 hembras y 535 machos; 25 hembras positivas y 29 machos positivos). La infección por TVT fue más frecuente en perros de 2-3 años. Se observó un patrón de agregación espacial en los casos locales. No hubo lesiones en los 29 animales tratados un año después. Conclusión: El TVT es una enfermedad común, y su distribución sugiere su agregación en ciertas áreas de la comunidad. Se requieren más estudios sobre la dinámica de la población de perros en ciudades pequeñas.

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Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy

Cited by 9 publications

References 18 publications

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Rethinking Antigen Source: Cancer Vaccines Based on Whole Tumor Cell/tissue Lysate or Whole Tumor Cell

Genetically modified cancer vaccines: Current status and future prospects

Prevalence and distribution of transmissible venereal tumor in dogs from a rural community of Mexico

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