Immunogenic human leukocyte antigen class II antigens on human cardiac valves induce specific alloantibodies

Hoekstra, Franciska; Witvliet, Marian D.; Knoop, C. J.; Wassenaar, C; Bogers, Ad J.J.C.; Weimar, Willem; Claas, Frans H.J.

doi:10.1016/s0003-4975(98)01058-3

Cited by 37 publications

(25 citation statements)

References 22 publications

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“…Moreover, we provided evidence that the PRA level continues to increase with time between 4 and 12 months. Our findings are consistent with those of other institutions [15][16][17][18]. Hoekstra et al found that panel reactive antibodies developed in 78% of 32 recipients of cardiac valve allografts [16].…”

Section: Discussionsupporting

confidence: 93%

“…Our findings are consistent with those of other institutions [15][16][17][18]. Hoekstra et al found that panel reactive antibodies developed in 78% of 32 recipients of cardiac valve allografts [16]. Smith et al similarly noted a strong donor HLA-specific antibody response with HLA antibodies detected in 56% of recipients of antibiotic-preserved allografts and 100% of homovital (fresh) allograft recipients [17].…”

Section: Discussionsupporting

confidence: 91%

“…This finding, to the best of our knowledge, has not been previously reported in the literature for this population. Others have also reported a failure to develop an elevated PRA in response to allograft tissue; however, in these studies the HLA mismatch was not reported and thus the reason for the failure to develop antibodies is unclear [12,16]. Admittedly, there is potential for the results to be confounded by the increased use of blood products in recipients of allograft tissue.…”

Section: Discussionmentioning

confidence: 97%

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Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation

Meyer

Campbell

Rutledge

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

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Use of an allograft patch in repair of hypoplastic left heart syndrome may complicate future transplantation

Meyer

Campbell

Rutledge

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…12 That homograft heart valves elicit a host-dependent immune response against the implanted tissue has been well described. 13,14 The concept of decellularization or tissue engineering of heart valves was developed and modified by several groups to circumvent these problems. [15][16][17][18] Tissue engineering is defined as the regeneration of biological tissue through the use of cells with the aid of supporting structures and/or biomolecules.…”

Section: Discussionmentioning

confidence: 99%

Tissue Engineering of Heart Valves

et al. 2005

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Background-Tissue-engineered or decellularized heart valves have already been implanted in humans or are currently approaching the clinical setting. The aim of this study was to examine the migratory response of human monocytic cells toward decellularized porcine and human heart valves, a pivotal step in the early immunologic reaction. Methods and Results-Porcine and human pulmonary valve conduits were decellularized, and migration of U-937 monocytic cells toward extracted heart valve proteins was examined in a transmigration chamber in vitro. Homogenized tissue specimens were size fractionated by SDS-PAGE. ). SDS-PAGE of the pulmonary heart valve tissue revealed that considerable amounts of proteins with different molecular weights that were not detected in the human equivalent remain in the decellularized porcine heart valve. Conclusions-We describe for the first time that the remaining potential of decellularized pulmonary heart valves to attract monocytic cells depends strongly on whether porcine or human scaffolds were used. These findings will have an important impact on further investigations in the field of heart valve tissue engineering.

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“…[17][18][19] Although homografts are processed and preserved, they remain immunologically reactive and can lead to HLA antibody formation. [19][20][21][22][23][24][25][26][27][28][29] These antibodies can be harmful to the transplanted graft. HLA antibody-mediated cardiac rejection (AMR), first described by Hammond and colleagues 30 in the late 1980s, is a considerable risk factor for poor outcomes after pediatric transplantation.…”

mentioning

confidence: 99%