Immunogenic cell death related mRNAs associated signature to predict immunotherapeutic response in osteosarcoma

Han, Shuai; Wang, Qinghe; Shen, Mingquan; Zhang, Xingpeng; Wang, Jian

doi:10.1016/j.heliyon.2024.e27630

Cited by 2 publications

(2 citation statements)

References 59 publications

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“…Previous studies have shown that different immune subtypes indicated various biological heterogeneity and treatment response [ 39 , 40 ]. Therefore, it is necessary to investigate the underlying molecular subtypes according to immune patterns to evaluate and improve individualized medical decisions for patients with OS.…”

Section: Discussionmentioning

confidence: 99%

Identification of immune-related tumor antigens and immune subtypes in osteosarcoma

Zhang,

Xu,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Identification of immune-related tumor antigens and immune subtypes in osteosarcoma

Zhang,

Xu,

et al. 2024

Heliyon

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“…Malignant Tumor tissues using Expression data) is an R package that outputs the ESTIMATE immune infiltration score (IS). 4 For a given sample, gene expression values are rank-normalized and ranked. The empirical cumulative distribution functions of genes in the feature and the remaining genes are calculated.…”

Section: Characterization Of Immune Features Estimate (Estimation Of ...mentioning

confidence: 99%

Complex immune microenvironment of chordoma: a road map for future treatment

Niu,

Zheng,

Zou

et al. 2024

J Immunother Cancer

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BackgroundChordoma, a rare bone tumor, presents limited treatment options and patients typically exhibit poor survival outcomes. While immunotherapy has shown promising results in treating various tumors, research on the immune microenvironment of chordomas is still in its early stages. Therefore, understanding how the immune microenvironment of chordomas influences the outcomes of immunotherapy is crucial.MethodsWe employed single-cell RNA sequencing (scRNA-seq), bulk RNA-seq, CellChat, gene set variation analysis, as well as calculation of immune features to further dissect the complex immune microenvironment of chordoma.ResultsPrevious research by van Oostet alargued that compared with other sarcomas, chordomas typically exhibit an immunologically “hot” microenvironment, a conclusion with which we concur based on their research findings. Additionally, the authors suggest that T cell-mediated immunotherapy is feasible for the majority of chordomas. However, we are inclined to categorize them as an immune-excluded phenotype according to the latest classification methods, rather than persisting with the concepts of “cold” and “hot”. Unlike them, we explored immune infiltration scores (IS), T lymphocyte scoring (TLS), and human leucocyte antigen class I (HLA-I) using Bulk RNA-seq data from 126 chordoma patients and found that higher IS, TLS, and higher HLA-I expression were associated with poorer patient prognosis. Additionally, CellChat analysis of scRNA-seq results from six chordoma patients revealed no direct interaction between T cells and tumor cells.ConclusionsThese findings suggested that the efficacy of T cell-based immunotherapy may be limited or even ineffective for patients with chordoma.

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Immunogenic cell death related mRNAs associated signature to predict immunotherapeutic response in osteosarcoma

Cited by 2 publications

References 59 publications

Identification of immune-related tumor antigens and immune subtypes in osteosarcoma

Identification of immune-related tumor antigens and immune subtypes in osteosarcoma

Complex immune microenvironment of chordoma: a road map for future treatment

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