Immunofluorescent Staining With Antibodies to Factor VIII, Fibronectin, and Collagenous Basement Membrane Protein in Normal Human Skin and Port Wine Stains

Finley, James M.

doi:10.1001/archderm.1982.01650240015012

Cited by 43 publications

(16 citation statements)

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“…Several studies have failed to demonstrate a difference between endothelial cells of capillary malformations and normal vessels (Finley et al 1982;Katagampola et al 1997;Lanigan 1998;Neumann et al 1994). Pericytes were found to be predominantly located in the inner part of the vessel wall (Schneider et al 1988).…”

Section: Discussionmentioning

confidence: 99%

A locus for hereditary capillary malformations mapped on chromosome 5q

et al. 2002

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Capillary malformations (port-wine stains) are the most common vascular malformations occurring in 0.3% of live births. Most capillary malformations occur sporadically and present as a solitary lesion. Capillary malformations can also occur as a component of well-described syndromes. Familial occurrence of multiple capillary malformations has been described in the literature, suggesting autosomal dominant inheritance with variable expression in this subgroup. A hereditary basis underlying the development of solitary capillary malformations has not been found, but may well be possible. We have mapped a locus for an autosomal dominant disorder in a three-generation family that manifested itself with multiple cutaneous capillary malformations to chromosome 5q13-22. This locus spans 48 cM between the markers D5S647 and D5S659 and harbours several candidate genes. By defining the gene(s) responsible for capillary malformations, we will gain more insight in the pathogenesis of this disorder. It is likely that genes implicated in these familial cases may be involved in the more sporadic cases.

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Section: Discussionmentioning

confidence: 99%

A locus for hereditary capillary malformations mapped on chromosome 5q

et al. 2002

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“…Biopsy specimens of PWS in infancy show no abnormalities, ectatic vessels first becoming histologically apparent at the age of 10 years. As a consequence, weakness of the vessel walls has been suggested as a cause of PWS but immunofluorescence studies of three important components of vessel wall (factor VIII‐related antigen, fibronectin and collagenous basement membrane protein) have failed to support this theory 5 …”

Section: Reportmentioning

confidence: 99%

Partial re-emergence of a port-wine stain following successful treatment with flashlamp-pumped dye laser

Ozluer

Barlow

2001

Clinical and Experimental Dermatology

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We present a 49-year-old patient with a congenital superficial vascular malformation of port-wine stain (PWS) type which has partially re-emerged in the 2.5 years since it was almost completely obliterated with the flashlamp-pumped short pulse pulsed-dye laser (FPDL). This observation is discussed with respect to the possible pathogenesis of PWS, with particular reference to the underlying autonomic nerve supply. The latter would not be expected to respond to FPDL and may explain re-emergence of the lesion.

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“…Abnormal innervation patterns have been described in capillary malformations (port wine stains), which are characterized by dilated post capillary venules [4] and a significant decrease in nervous innervation [5]. However, capillary malformations have a relatively normal vasculature [6], and even the amount of vessels in the malformation is not increased compared to the normal skin, which clearly separates them from vascular malformations composed of large vessels. Another study documented the presence of nerve bundles in 91% of cases of AVM versus no intralesional nerves in hemangioma, which according to the authors may be helpful in the differential diagnosis of both lesions [7].…”

Section: Introductionmentioning

confidence: 99%