Immunofluorescent localization of renin in mouse submaxillary gland and kidney.

Menzie, James W.; Hoffman, Loren H.; Michelakis, Andrew M.

doi:10.1152/ajpendo.1978.234.5.e480

Cited by 11 publications

(1 citation statement)

References 15 publications

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“…Although EGF and renin have been localized immunocytochemically in GCT cells of the submandibular gland (Turkington et al, 1971;van Noorden et al, 1977;Gresik and Barka, 1977;Menzie et al, 1978;, immunoreactive proteases, including kallikreins, have been demonstrated in some cells of the striated ducts of all three major salivary glands under normal conditions (Ekfors and Hopsu-Havu, 1971;Orstavik et al, 1975;Simson et al, 1979;Gresik et al, 1981a). However, the subcellular components responsible for this subluminal staining have not yet been identified.…”

Section: Hormonally Treated Female Micementioning

confidence: 99%

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Gresik

Barka

1983

Anat. Rec.

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In the striated ducts of the sublingual glands of normal adult male, but not female, Swiss-Webster mice a few scattered cells have apical secretion granules. These sublingual duct cells resemble the granular convoluted tubule (GCT) cells of the submandibular glands of adult female mice, in that they are smaller than submandibular GCT cells of adult males, and contain fewer apical granules, and prominent basal striations. These cells stain immunocytochemically for epidermal growth factor (EGF), renin, and protease A. Such granular striated duct cells could be induced in the sublingual glands of adult female mice by treatment with either testosterone propionate or thyroxine; the two hormones given simultaneously acted synergistically in this induction.

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Section: Hormonally Treated Female Micementioning

confidence: 99%

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Gresik

Barka

1983

Anat. Rec.

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Immunohistochemical demonstration of renin in the juxtaglomerular apparatus of three Bufo species

et al. 1985

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The cellular localization of renin was examined in the kidneys of some amphibians of the genus Bufo by immunoperoxidase and immunofluorescence techniques with an antiserum to renin isolated from the submandibular gland of the mouse. Immunoreactivity could be demonstrated in the media cells of the afferent arterioles (juxtaglomerular cells) close to as well as at great distance from the glomeruli. Occasionally, media cells of larger arterial vessels were also stained. The immunohistochemical data seem to be in accordance with earlier results obtained with a modified silver impregnation technique (Movat's staining procedure) used for the visualization of juxtaglomerular cells in non-mammalian vertebrates. Mouse kidney tissue, studied for purposes of comparison, showed renin-immunoreactivity as described by earlier investigators, i.e., immunoreactive staining in the afferent arterioles near the glomeruli and in the proximal tubule cells.

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Immunocytochemical localization and concentrations of the ? and ? subunits of 7S-nerve growth factor in the submandibular gland of the mouse

1984

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For unexplained reasons, nerve growth factor (NGF) exists in very high concentrations in the submandibular gland of the mouse. The NGF in the gland, called 7S-NGF, is a non-covalent complex of three protein subunits, named alpha-, gamma- and beta-NGF. All the known biological activity resides in the beta-NGF subunit, and previous studies have shown that beta-NGF is present in much greater concentrations in the male submandibular gland than in the female gland. The higher concentration in the male is due to the fact that beta-NGF is synthesized in the granular tubule cells of the submandibular gland. These cells are much more numerous in the male gland. In contrast to beta-NGF, neither the concentrations of alpha and gamma subunits nor their cellular localization in the mouse submandibular gland have been established. In this study, radioimmunoassays specific for alpha and gamma subunits determined that both are present in much higher concentrations in the male gland. Immunocytochemical work localized both subunits in the granular tubule cell in the male and female submandibular gland. This indicates that all the components of 7S-NGF exist in a single cell type in the gland and suggests that 7S-NGF can be formed within this cell and secreted as a complex into the saliva.

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Immunofluorescent localization of renin in mouse submaxillary gland and kidney.

Cited by 11 publications

References 15 publications

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Epidermal growth factor, renin, and protease in hormonally responsive duct cells of the mouse sublingual gland

Immunohistochemical demonstration of renin in the juxtaglomerular apparatus of three Bufo species

Immunocytochemical localization and concentrations of the ? and ? subunits of 7S-nerve growth factor in the submandibular gland of the mouse

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