2012
DOI: 10.4103/0378-6323.102355
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Immunofluorescence in dermatology

Abstract: Direct immunofluorescence (DIF) and indirect immunofluorescence (IIF) tests on skin biopsy are being done mostly in academic teaching hospitals. These tests provide a useful diagnostic aid to dermatologists. Immunohistology and serology can, in conjunction with histology, provide considerable help in delineation and diagnosis of various skin disorders as well as systemic diseases with skin involvement, e.g. systemic lupus erythematosus. Immunofluorescence (IF) studies have now become an invaluable supplement t… Show more

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Cited by 43 publications
(69 citation statements)
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“…The role of DIF techniques on Tzanck smear samples has also been evaluated for the diagnosis of pemphigus vulgaris, and the results were found to be comparable with respective skin biopsies in the same set of patients. Thus, Tzanck smear can be used as a substitute to biopsy (25). In our case, IgA deposits were present on the individual cells and in the intercellular substances where the cells were present in clusters.…”
Section: Discussionmentioning
confidence: 84%
“…The role of DIF techniques on Tzanck smear samples has also been evaluated for the diagnosis of pemphigus vulgaris, and the results were found to be comparable with respective skin biopsies in the same set of patients. Thus, Tzanck smear can be used as a substitute to biopsy (25). In our case, IgA deposits were present on the individual cells and in the intercellular substances where the cells were present in clusters.…”
Section: Discussionmentioning
confidence: 84%
“…Direct immunofluorescence (DIF) of skin biopsy of unblistered, perilesional skin (normal-looking skin) reveals linear deposition of IgG and/or complement 3(C3) along the basement membrane zone (BMZ). Indirect immunofluorescence (IIF) shows presence of circulating IgG anti-basement membrane zone antibodies [1][2][3][4]. We report a case of childhood bullous pemphigoid whose skin biopsy showed subepidermal blisters with dermal layer infiltrated with neutrophils.…”
Section: Introductionmentioning
confidence: 99%
“…In epidermolysis bullosa acquisita, intense IgG deposition is present [2] . The intensity of C3 deposition is usually less than that of IgG (Figure 4).…”
Section: Epidermolysis Bullosa Acquisitamentioning
confidence: 99%
“…Direct Immunofluorescence of perilesional skin in pemphigus exhibit linear or granular pattern of deposition of immunoglobulins and C3 in the epidermal intercellular spaces [2] . It reveals uniform "fish like net pattern" or "chicken wire pattern" (Figure2).…”
Section: Pemphigus Vulgarismentioning
confidence: 99%
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