Immunofluorescence findings in granuloma faciale: report of two cases

Zirwas, Matthew J.; Abell, Edward; Ruben, Alan; Silverman, Alan R.; Wolff, Jeffrey; Deng, Jau‐Shyong

doi:10.1034/j.1600-0560.2003.00051.x

Cited by 12 publications

(5 citation statements)

References 13 publications

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“…DIF exam of both GF and EED lesions has demonstrated both vascular and/or basement membrane zone complement and immunoglobulin deposits. 105,106,109,110 In the case of GF, these DIF findings suggest that it is a vasculitis mediated by IC, maintained by an unidentified, local persistent antigen or regionally produced IC. 110 Lastly, rare reports exist of solitary cutaneous lesions with histologic features similar to those of EED or GF, but whose clinical picture are not those of either disease; these cases have been termed ''inflammatory pseudotumors'' of the skin.…”

Section: Malignancy-induced Vasculitismentioning

confidence: 92%

Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

Carlson

Kr²

2006

The American Journal of Dermatopathology

182

151

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A broad and diverse spectrum of vasculitic syndromes exists. These syndromes affect the skin with varying levels of associated systemic manifestations, running the gamut from a self-limited, localized, cutaneous phenomenon to rapidly progressive, multiorgan disease. The majority of cases of cutaneous vasculitis will show a neutrophilic small vessel vasculitis that can be either a primary (idiopathic) disorder (eg, cutaneous leukocytoclastic angiitis) or a secondary disorder that is associated with drugs, infection (eg, streptococcal infection, viral hepatitis), or underlying disease (eg, connective tissue disease, malignancy). Biopsy is the gold standard for the diagnosis of cutaneous vasculitis and also necessary for the detection of cutaneous vascular immune complexes by direct immunofluorescence. Based on the type of vessel disrupted by inflammation (small and/or muscular), the distribution of vasculitis in the dermis and subcutis, and predominate inflammatory cell-type mediating vessel wall damage, a list of relevant differential diagnoses can be generated. This histologic information coupled with extravascular findings such as tissue eosinophilia, tissue neutrophilia, and/or granulomas, plus pathophysiologic markers such as direct immunofluorescent examination for immune complexes and serologic evaluation for antineutrophil cytoplasmic antibodies allows for more accurate diagnosis of specific vasculitic entities. Herein, we review both primary and secondary vasculitic syndromes that affect the skin and show a small vessel neutrophilic mediated vasculitis.

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Section: Malignancy-induced Vasculitismentioning

confidence: 92%

Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

Carlson

Kr²

2006

The American Journal of Dermatopathology

182

151

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“…Ocorre sobretudo em adultos. [65][66][67][68] O diagnóstico é clínico e histopatológico. São diagnósticos diferenciais os linfomas, pseudolinfomas, sarcoidose, sífilis, lúpus túmido, hanseníase, rosácea granulomatosa e erupção polimorfa à luz.…”

Section: Granuloma Facialunclassified

Vasculites dos médios e grandes vasos

Brandt

Arnone

Valente

et al. 2009

An. Bras. Dermatol.

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Resumo:As vasculites são constituídas por um grande grupo de síndromes caracterizadas por inflamação e necrose da parede dos vasos sangüíneos, resultando em estreitamento ou oclusão do lúmen. A distribuição dos vasos envolvidos varia consideravelmente e serve de base para a classificação das síndromes vasculíticas: grandes vasos (arterite de Takayasu, arterite temporal); pequenos e médios vasos (poliarterite nodosa, síndrome de Churg-Strauss, granulomatose de Wegener, vasculites nas doenças reumáticas); e pequenos vasos (vasculite de hipersensibilidade, púrpura de Henoch-Schonlein, poliangeíte microscópica, crioglobulinemia). Este artigo revisa as vasculites dos médios e grandes vasos e opções terapêuticas atuais; além de oferecer orientação sobre abordagem diagnóstica e tratamento dos pacientes com suspeita de vasculite cutânea. Palavras-chave: Anticorpos anticitoplasma de neutrófilos; Arterite de células gigantes; Arterite de Takayasu; Doenças reumáticas; Granulomatose de Wegener; Poliarterite nodosa; Púrpura; Síndrome de Churg-Strauss; Vasculite; Vasculite alérgica cutânea Abstract: Vasculitis comprises a broad group of syndromes characterized by inflammation and necrosis on the walls of blood vessels, resulting in narrowing or occlusion of the lumen. The distribution of involved blood vessel varies considerably and serves as the basis for one classification of vasculitic syndromes: large vessels (Takayasu arteritis, giant cell arteritis); medium and small muscular arteries (polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, vasculitis in rheumatic diseases); and small vessels ("hypersensitivity" vasculitis, Henoch-Schonlein purpura, microscopic polyangiitis, cryoglobulinemia). This article reviews medium and large vessel vasculitis and current treatment options; it also presents a comprehensive approach to diagnosing and treating patients with suspected cutaneous vasculitis.

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“…Granuloma faciale (Figure ) and erythema elevatum et diutinum are chronic forms of leukocytoclastic vasculitis , persisting for months to years . The vasculitic process manifests with perivascular accentuation of neutrophils and nuclear dust against the backdrop of fibrosing dermatitis (Table ).…”

Section: Small Vessel Vasculitismentioning

confidence: 99%

Vasculitic wheel – an algorithmic approach to cutaneous vasculitides

Ratzinger

Zelger

Carlson

et al. 2015

J Deutsche Derma Gesell

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SummaryBackground: Previous classifications of vasculitides suffer from several defects. First, classifications may follow different principles including clinicopathologic findings, etiology, pathogenesis, prognosis, or therapeutic options. Second, authors fail to distinguish between vasculitis and coagulopathy. Third, vasculitides are systemic diseases. Organ-specific variations make morphologic findings difficult to compare. Fourth, subtle changes are recognized in the skin, but may be asymptomatic in other organs. Our aim was to use the skin and subcutis as a model and the clinicopathologic correlation as the basic process for classification. Methods and Results:We use an algorithmic approach with pattern analysis, which allows for consistent reporting of microscopic findings. We first differentiate between small and medium vessel vasculitis. In the second step, we differentiate the subtypes of small (capillaries versus postcapillary venules) and medium-sized (arterioles/arteries versus veins) vessels. In the final step, we differentiate, according to the predominant cell type, into leukocytoclastic and/or granulomatous vasculitis. Conclusions: Starting from leukocytoclastic vasculitis as a central reaction pattern of cutaneous small/medium vessel vasculitides, its relations or variations may be arranged around it like spokes of a wheel around the hub. This may help establish some basic order in this rather complex realm of cutaneous vasculitides, leading to a better understanding in a complicated field.

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Immunofluorescence findings in granuloma faciale: report of two cases

Cited by 12 publications

References 13 publications

Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

Vasculites dos médios e grandes vasos

Vasculitic wheel – an algorithmic approach to cutaneous vasculitides

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