2013
DOI: 10.1590/s0102-86502013001000001
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Immunoexpression of proliferating cell nuclear antigen (PCNA) in spleen of splenectomized rats with preservation of inferior pole, submitted to hyperbaric oxygenation

Abstract: PURPOSE:To analyze PCNA immunoexpression on the inferior pole of the spleen of splenectomized rats submitted to hyperbaric oxygenation (HBO). METHODS:Were analyzed fragments of the inferior pole of the spleen of 20 male Wistar rats submitted to splenectomy with preservation of the inferior pole. The rats were divided in two groups: group A (n=10) without HBO and group B (n=10) submitted to HBO at 2, 5 atmospheres per 120 minutes, twice a day for three days and once a day for seven days. The groups were then su… Show more

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Cited by 4 publications
(5 citation statements)
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“…Studies with different experimental models showed significant changes in the lipid profile of the splenectomized animals 1,6,7,9,[19][20][21][22] . However, when part of the spleen is preserved, its viability is maintained [23][24][25] closer to the metabolic profile of humans due to the strong controversies and high morbidity and mortality rates caused by complications from the atherosclerotic disease.…”
Section: Discussionmentioning
confidence: 99%
“…Studies with different experimental models showed significant changes in the lipid profile of the splenectomized animals 1,6,7,9,[19][20][21][22] . However, when part of the spleen is preserved, its viability is maintained [23][24][25] closer to the metabolic profile of humans due to the strong controversies and high morbidity and mortality rates caused by complications from the atherosclerotic disease.…”
Section: Discussionmentioning
confidence: 99%
“…Ki67 antigen is an important biomarker for the assessment of tumor cell proliferation [ 11 ]. PCNA is a major biological index of cell proliferation, which can objectively reflect the proliferation of tumor cells [ 12 ]. The p21 protein is a cyclin-dependent kinase(cdk) inhibitory protein that functions as a cell cycle regulator to block the transition from G1 phase to S phase, thus suppressing cell proliferation [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Considering the risks inherent to total splenectomy, the spleen's partial preservation is recommended 7,10,11,[17][18][19][20] .…”
Section: Introductionmentioning
confidence: 99%