Immunoexpression and prognostic significance of TIMP-1 and -2 in oral squamous cell carcinoma

Vicente, Juan Carlos de; Fresno, Manuel; Villalaín, Lucas de; Vega, J.A.; Arranz, J. S. López

doi:10.1016/j.oraloncology.2004.12.008

Cited by 31 publications

(21 citation statements)

References 36 publications

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“…Although S-100 protein antibodies are widely available and may aid in identification of peripheral nerves, we surmise that antibodies targeting the perineurium may be most helpful when evaluating the relationship between the perineurium and adjacent tumor. However, EMA, GLUT1, and claudin-1 may be expressed by not only perineurium but also OSCC [24][25][26]. Also of interest, in a study of PNI in colorectal cancer staging by Ueno et al [27], GLUT1 immunohistochemistry showed tumor outside the perineurium even in a case regarded as a typical example of PNI based on hematoxylin and eosin staining (i.e., tumor surrounding most of the circumference of a nerve).…”

Section: Does Not Address Intraneural Invasionmentioning

confidence: 99%

Interobserver Variation Among Pathologists in Evaluating Perineural Invasion for Oral Squamous Cell Carcinoma

Chi

Chen

Katabi³

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Does Not Address Intraneural Invasionmentioning

confidence: 99%

Interobserver Variation Among Pathologists in Evaluating Perineural Invasion for Oral Squamous Cell Carcinoma

Chi

Chen

Katabi³

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…They can suppress angiogenesis, tumor invasion and metastasis in vivo, but especially TIMP-2 seems to have a dual function and is capable of activating MMP-2 and independently regulating cell growth and survival [26]. A study of TIMP expression in OSCC by De Vicente et al [25] revealed that TIMP-2 expression correlated signiWcantly with tumor stage, local recurrence and survival outcome, while TIMP-1 showed no relation to clinicopathological parameters. A complete understanding of the pathophysiological features of MMPs and TIMPs is still lacking.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

Grimminger

Danenberg

2010

Eur Arch Otorhinolaryngol

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Oropharyngeal squamous cell carcinomas (OSCC) constitute about 5% of all cancers in the western world and the incidence and mortality rates of this tumor have shown little improvement over the last 30 years. Molecular targeted therapy, a promising strategy for the treatment of OSCC and other cancers, requires the understanding of specific molecular events of carcinogenesis and the different pathological, partly interrelated pathways. Extended knowledge of the prognostic or predictive value of molecular biomarkers in oropharyngeal cancer is necessary to allow a better characterization and classification of the tumor, improve the appraisal of clinical outcome and help to specify individual multimodal therapy with increased efficiency. This work affords an updated summary regarding recent data about tissue biomarkers in patients with OSCC, based on the six essential hallmarks of cancer described by Hanahan and Weinberg (Cell 100(1):57-70, 2000) providing the characterization of a malignant cell.

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“…The role of MMPs in metastasis of OSCCs is well established [90, 123, 124, 149–154] and highlighted by their presence in metastasis-related gene signatures [120, 125, 127, 128, 131, 135, 141, 155]. …”

Section: Highlights Of the Advances In The Understanding Of Lymph mentioning

confidence: 99%

Gene Expression Signatures of Lymph Node Metastasis in Oral Cancer: Molecular Characteristics and Clinical Significances

Liu¹,

Kolokythas²,

Wang³

et al. 2010

CCTR

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Even though lymph node metastasis accounts for the vast majority of cancer death in patients with oral cancer (OC), the molecular mechanisms of lymph node metastasis remain elusive. Genome-wide microarray analyses and functional studies in vitro and in vivo, along with detailed clinical observations, have identified a number of molecules that may contribute to lymph node metastasis. These include lymphangionenic cytokines, cell adhesion molecules, basement membrane-interacting molecules, matrix enzymes and relevant downstream signaling pathways. However, defined gene signatures from different studies are highly variable, which hinders their translation to clinically relevant applications. To date, none of the identified signatures or molecular biomarkers has been successfully implemented as a diagnostic or prognostic tool applicable to routine clinical practice. In this review, we will first introduce the significance of lymph node metastasis in OC, and clinical/experimental evidences that support the underlying molecular mechanisms. We will then provide a comprehensive review and integrative analysis of the existing gene expression studies that aim to identify the metastasis-related signatures in OC. Finally, the remaining challenges will be discussed and our insights on future directions will be provided.

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Immunoexpression and prognostic significance of TIMP-1 and -2 in oral squamous cell carcinoma

Cited by 31 publications

References 36 publications

Interobserver Variation Among Pathologists in Evaluating Perineural Invasion for Oral Squamous Cell Carcinoma

Interobserver Variation Among Pathologists in Evaluating Perineural Invasion for Oral Squamous Cell Carcinoma

Update of prognostic and predictive biomarkers in oropharyngeal squamous cell carcinoma: a review

Gene Expression Signatures of Lymph Node Metastasis in Oral Cancer: Molecular Characteristics and Clinical Significances

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