Immunoelectronmicroscopic examination of early lesions in histamine induced immune complex vasculitis in man

Wolff, Helmut H.; Maciejewski, Wojciech; Scherer, R.; Braun‐Falco, Otto

doi:10.1111/j.1365-2133.1978.tb01955.x

Cited by 44 publications

(14 citation statements)

References 19 publications

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“…So we regard these findings to be an early phase of im mune complex vasculitis. This interpreta tion is in accordance with previous reports of direct IF on histamine-induced early vas culitis lesions in patients with allergic vascu litis [2,24], Interestingly, the BD patient had no oral aphthae at the time of investigation, the other patient had only C3 deposits in subepithelial vessel walls of oral aphthous lesion.…”

Section: Discussionsupporting

confidence: 81%

“…Though not revealed by direct IF in the present study, C3 deposits in lesional vessel walls may indicate the presence of immune complexes which already have been removed by chcmotactically attracted polymorphonuclear leukocytes. Detection of C3 alone in biopsies taken from visible vasculitic skin lesions is a common finding [2,22,24], Thus, tissue-bound C3 in late phase leukocytoclastic vasculitis only repre sents the remnant of the process leading to complement activation by immune com plexes.…”

Section: Discussionmentioning

confidence: 99%

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Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet’s Disease

1983

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Direct immunofluorescence (IF) investigations in oral aphthae were performed in 17 patients with recurrent aphthous ulcers (RAU) and in 9 patients with Behçet’s disease (BD). In addition, cutaneous hyperreactivity lesions from 2 BD patients were examined. The results were compared to direct IF findings in 28 patients with nonaphthous oral diseases. There was no difference between direct IF on oral aphthae in RAU compared to BD. Deposition of C3 in vessel walls of the subepithelial connective tissue was observed in 13 of 17 patients with RAU and in all patients with BD. IgM deposits in vessel walls were found in 5 RAU and 3 BD patients. Deposition of C1q or C4 was not present. By contrast, IgG and/or IgM, C1q, C3 and C4 were detected in dermal vessel walls of skin hyperreactivity lesions from 2 BD patients. This finding is considered to be a true immune complex vasculitis. Compared to nonaphthous oral lesions, oral aphthae of BD and RAU were characterized by C3 deposition in the subepithelial vessel walls.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet’s Disease

1983

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“…We injected histamine in healthy skin of patients' legs to provoke circulating im mune-complex precipitation in dermal ves sel walls. This method has been widely used in a variety of dermatoses where immune complexes may play a role [7,8].…”

Section: Resultsmentioning

confidence: 99%

“…1 ml of histamine (1:10,000) or saline as control into the hcalthy-looking skin of patients' legs 30 min. before the biopsy was taken [7,8]. Tissue samples were obtained from 12 patients.…”

Section: Methodsmentioning

confidence: 99%

Necrobiosis lipoidica: Clinical and Immunofluorescent Study

Laukkanen¹,

Fräki²,

Väätäinen³

et al. 1986

Dermatology

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Fourteen patients with necrobiosis lipoidica (NL) were carefully evaluated clinically and histologically. Ten of these patients (71%) had diabetes and most of them were treated with insulin (8 of 10 patients). Trauma was found as an immediate triggering factor in 6 patients (43%) and a possible preceding factor in 3 more cases. No immunoglobulins were found in the lesional skin of NL. Intradermal injections of histamine in healthy skin of legs led to deposition of immunoglobulins and complement (C3) in skin blood vessel walls in 4 of 12 patients studied (30%). These results suggest that immune complexes might be involved only in few cases of NL. Preceding trauma combined with metabolic and inflammatory changes could be an important triggering factor in the etiology of NL.

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“…Dur ing the last 6 years, numerous techniques [5,18,19,24] have been used for detecting IC-like substances in sera of patients with cutaneous vasculitis.…”

Section: Introductionmentioning

confidence: 99%

Antigenic Similarities within Circulating Immune Complexes in Patients Suffering from Cutaneous Vasculitis

Dambuyant¹,

Thivolet²

1981

Dermatology

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Circulating immune complexes (IC) were searched by 2% polyethylene glycol precipitation in 24 patients with clear-cut clinical cutaneous vasculitis. 13 patients were IC-positive. Isolated IC were shown to cross-react specifically within three different groups. One group possessed the same or highly similar antigenic determinants in circulating IC. No correlation was found between common antigenic determinants in IC and the histological and clinical features of the disease.

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Immunoelectronmicroscopic examination of early lesions in histamine induced immune complex vasculitis in man

Cited by 44 publications

References 19 publications

Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet’s Disease

Direct Immunofluorescence in Recurrent Aphthous Ulcers and Behçet’s Disease

Necrobiosis lipoidica: Clinical and Immunofluorescent Study

Antigenic Similarities within Circulating Immune Complexes in Patients Suffering from Cutaneous Vasculitis

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