Immunoelectron microscopic studies on peripheral T-cell lymphomas using monoclonal antibodies

Shamoto, Mikihiro; Kito, Kuniyoshi; Akatsuka, Hiromichi; Suchi, Taizan

doi:10.1007/bf02890211

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…A few tumours of ATLL, especially of the medium sized cell variant, have been shown to express simultaneously, on some, or even on most of their cells, CD4 and CD8 antigens, but the cells are negative for thymus cortex antigen (CD1). 98 We have already reported37 that the virus positive lymphomas differ considerably from the negative cases in their expression of antibodies; virus positive cases are consistently CD7 negative, but have IL2 receptors. The prognosis in the pleomorphic medium sized and large cell T lymphomas is generally extremely grave, but is worst in ATLL (median survival time 4-7 months).…”

Section: Adult T Cell Leukaemia/lymphoma (A Tll)682smentioning

confidence: 93%

Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification.

et al. 1987

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Section: Adult T Cell Leukaemia/lymphoma (A Tll)682smentioning

confidence: 93%

Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification.

et al. 1987

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T-Cell lymphoma revealed by a peripheral neuropathy: A report of two cases with an immunohistologic study on lymph node and nerve biopsies

Gherardi¹,

Gaulard²,

Prost³

et al. 1986

Cancer

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In two patients a peripheral neuropathy was the presenting symptom of a noncutaneous peripheral T-cell lymphoma. In the first patient, the neuropathy had a relapsing and remitting course, the symptoms improved under corticosteroid therapy. The second patient suffered from a relentless neuropathy. In both cases the lymphoma infiltrated the peroneal nerve with an angiocentric and perivascular pattern resembling that observed in central nervous system lymphomas. The characterization of T-cell subsets in the lymph node showed cells with the helper/inducer and suppressor/cytotoxic phenotype in the first case and a predominance of cells with the helper/inducer phenotype in the second case. In the nerve, lymphocytes beard the helper/inducer phenotype antigen. A typical paraneoplastic vasculitis of nerve showed clearly different immunologic features.

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The presence of particles resembling human T-cell leukemia virus type I at ultrastructural examination of lymphomatous cells in a case of T-cell leukemia/lymphoma

Vital

Moynet

et al. 1993

Cancer

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Background. Cases of adult T‐cell leukemia/lymphoma (ATLL) resulting from human T‐cell leukemia virus type I (HTLV‐I) have been observed mainly in the southern part of Japan. Recently, the authors performed a second examination of cutaneous, muscle, and nerve biopsy specimens from a French white woman who died of ATLL in 1979. Methods. A 67‐year‐old white woman had a lymphoma diagnosed on a lymph node biopsy. She then had acute pains and a thickened skin on both legs. Blood examination showed a leukocyte count of 16,000/ml with 75% leukemia T‐cells. Biopsies were performed on the antero‐external surface of the right leg. She died after 2 years of illness. Results. Lymphomatous infiltrates of T‐cell origin were seen in the dermis, between muscle fibers, and in a peripheral nerve. The recent ultrastructural examination of a few vacuoles located in the cytoplasm of certain lymphomatous cells showed rounded structures mixed with larger virus‐like formations having a central nucleoid and spike material around the envelope. Polymerase chain reaction experiments performed on deparaffinized sections demonstrated the presence of a tax sequence homologous to that of HTLV‐I. Other structural genes were not detected. Conclusions. These results contrast with other ultrastructural studies in which HTLV‐I was detected only after cultivation of leukemia cells from patients with ATLL. This case probably resulted from an HTLV‐I variant.

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Immunoelectron microscopic studies on peripheral T-cell lymphomas using monoclonal antibodies

Cited by 6 publications

References 9 publications

Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification.

Histopathology and immunohistochemistry of peripheral T cell lymphomas: a proposal for their classification.

T-Cell lymphoma revealed by a peripheral neuropathy: A report of two cases with an immunohistologic study on lymph node and nerve biopsies

The presence of particles resembling human T-cell leukemia virus type I at ultrastructural examination of lymphomatous cells in a case of T-cell leukemia/lymphoma

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