Immunodiffusion test for serodiagnosing subcutaneous zygomycosis

Kaufman, Leo; Mendoza, Leonel; Standard, P G

doi:10.1128/jcm.28.9.1887-1890.1990

Cited by 66 publications

(31 citation statements)

References 4 publications

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“…An immunodiffusion test is sensitive and specific for B. ranarum, with no cross-reactivity with other species of the order Entomophthorales, and can be used to monitor its resolution. 2,12 There is no standard treatment for all forms of the disease. Therapeutic trials showed variations in the response rate.…”

Section: Reportmentioning

confidence: 99%

Concurrent subcutaneous and visceral basidiobolomycosis in a renal transplant patient

Choonhakarn

Inthraburan

2004

Clin Exp Dermatol

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Basidiobolomycosis is a chronic inflammatory disease that occurs exclusively in healthy individuals. Clinically, the infection is generally restricted to subcutaneous tissue; however, the disease has been documented to emerge in visceral organs but seldom spreads to cause disseminated infection. We describe the first culture-confirmed case of systemic Basidiobolus ranarum infection in an immunosuppressed patient. A 55-year-old female renal transplant recipient developed chronic hard nonpitting oedema of the right lower extremity and abdominal wall concurrent with the infection from the same organism involving the uterus, urinary bladder and intra-abdominal lymph nodes. The patient responded successfully, both clinically and radiographically, to medical therapy without surgical resection. The treatment regimen consisted of potassium iodide and trimethoprim/sulfamethoxazole for 3 months, and the patient remains clear of symptoms after 10 months' follow-up.

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Section: Reportmentioning

confidence: 99%

Concurrent subcutaneous and visceral basidiobolomycosis in a renal transplant patient

Choonhakarn

Inthraburan

2004

Clin Exp Dermatol

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“…Conidiobolomycosis can also be identified from clinical tissue samples by PCR (Imhof et al 2003) or by an immunodiffusion test, using serum from the affected horse (Kaufman et al 1990;Steiger and Williams 2000).…”

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confidence: 99%

Conidiobolomycosis

Schumacher

Schumacher²

2007

Equine Veterinary Education

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“…In microbiologic cultures of C coronatus some conidia show villose appendages, a unique feature that allows definitive diagnosis by differentiating the organism from other zygomycetes reported to infect horses (eg, C lamprauges, B ranarum, and B haptosporus). 3,13,16,17 A recently developed immunodiffusion test helps to identify infection caused by C coronatus. 16 In this test, serum is examined for the precipitation of its antibodies with antigen from C coronatus grown in culture (concentrated cultured filtrate antigen, [CFA]).…”

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confidence: 99%

“…3,13,16,17 A recently developed immunodiffusion test helps to identify infection caused by C coronatus. 16 In this test, serum is examined for the precipitation of its antibodies with antigen from C coronatus grown in culture (concentrated cultured filtrate antigen, [CFA]). Serum from rabbits immunized with CFA form 5 precipitins with CFA in a control agar, which serves as a reference to identify precipitation lines of diagnostic sera.…”

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confidence: 99%

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Granulomatous Tracheitis Caused by Conidiobolus coronatus in a Horse

Williams

2000

J Vet Int Med

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A 9-year-old American Quarter Horse mare was examined for evaluation of harsh respiratory sounds and coughing made during exercise and serosanguinous bilateral nasal discharge that had been present for 3 months. The mare initially was treated with ceftiofur sodium by the referring veterinarian (Naxel, Upjohn; 2.2 mg/kg IM q12h) for five days and then with procaine penicillin G (22.000 IU/kg IM q12h) and gentamicin sulfate (6.6 mg/kg IM q24h) for 7 days. Despite treatment, clinical signs did not change.The mare was in good physical condition and showed good appetite and normal behavior. Rectal temperature was 37.9ЊC; heart rate at rest was 36 beats per minute, and respiratory rate was 20 breaths per minute. The mare had a slight, odorless, bilateral mucohemorrhagic nasal discharge and mild inspiratory and expiratory sounds, but abnormal lung sounds were not heard during auscultation. Mandibular and retropharyngeal lymph nodes were not enlarged or painful on palpation. Tracheal rings felt firm and thickened on palpation. Nasal passages, guttural pouches, and the larynx appeared normal during endoscopic examination. Endoscopy of the trachea, however, revealed numerous granulomatous and partially erosive lesions in the proximal half of the trachea that had narrowed the tracheal lumen (Fig. 1). A cytological smear of the transendoscopical aspirate taken from the areas with granulomatous changes in the mucosa was highly cellular, with no evidence of bacteria, fungi, or neoplastic cells. Sixty percent of the cells were nondegenerate segmented neutrophils, and 40% were eosinophils. Fibrinogen concentration, results of a CBC, and serum biochemistries were within the reference range. Radiography showed an irregular tracheal lining extending the entire length of the tracheal lumen. Radiographic lesions within the lungs were not observed. Alpha-hemolytic Streptococcus spp. and a few colonies of gram-negative rods, most likely Actinobacillus sp., were cultured aerobically from tissue obtained by transendoscopic biopsy of granulomatous tracheal lesions.Intense infiltration of the submucosa with predominantly eosinophils, lesser numbers of neutrophils, and still fewer macrophages was found during histologic examination of the biopsy tissue. Multiple hypereosinophilic, 100-300-m foci with a central clear zone surrounded by degranulated eosinophilic granulocytes and nuclear debris (Splendore-

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Immunodiffusion test for serodiagnosing subcutaneous zygomycosis

Cited by 66 publications

References 4 publications

Concurrent subcutaneous and visceral basidiobolomycosis in a renal transplant patient

Concurrent subcutaneous and visceral basidiobolomycosis in a renal transplant patient

Conidiobolomycosis

Granulomatous Tracheitis Caused by Conidiobolus coronatus in a Horse

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