Immunodiagnostics of Tuberculosis: 10-Year Experience of Using Immunological Tests in Russia

Старшинова, Анна; Довгалюк, И. Ф.; Яблонский, П. К.

doi:10.21292/2075-1230-2019-97-5-58-65

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Skin tests have historically been widely used since the time of Robert Koch because they are simple to use, low-cost, and highly informative [45,46]. Today, while there is no doubt about the high sensitivity of the Mantoux test with 2 TU, in the context of vaccination against TB, the test has a low specificity [47,48].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Tuberculosis: Mathematical Modeling of Infection Spread Taking into Account Reduced Screening

Starshinova,

Osipov,

Dovgalyk

et al. 2024

Diagnostics

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The COVID-19 pandemic resulted in the cessation of many tuberculosis (TB) support programs and reduced screening coverage for TB worldwide. We propose a model that demonstrates, among other things, how undetected cases of TB affect the number of future M. tuberculosis (M. tb) infections. The analysis of official statistics on the incidence of TB, preventive examination coverage of the population, and the number of patients with bacterial excretion of M. tb in the Russian Federation from 2008 to 2021 is carried out. The desired model can be obtained due to the fluctuation of these indicators in 2020, when the COVID-19 pandemic caused a dramatic reduction in TB interventions. Statistical analysis is carried out using R v.4.2.1. The resulting model describes the dependence of the detected incidence and prevalence of TB with bacterial excretion in the current year on the prevalence of TB with bacterial excretion in the previous year and on the coverage of preventive examinations in the current and previous years. The adjusted coefficient of model determination (adjusted R-squared) is 0.9969, indicating that the model contains almost no random component. It clearly shows that TB cases missed due to low screening coverage and left uncontrolled will lead to a significant increase in the number of new infections in the future. We may conclude that the obtained results clearly demonstrate the need for mass screening of the population in the context of the spread of TB infection, which makes it possible to timely identify patients with TB with bacterial excretion.

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Section: Discussionmentioning

confidence: 99%

COVID-19 and Tuberculosis: Mathematical Modeling of Infection Spread Taking into Account Reduced Screening

Starshinova,

Osipov,

Dovgalyk

et al. 2024

Diagnostics

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Abdominal tuberculosis in children

Soloviev¹,

Vasin²,

Efimov³

2022

Khir. Z. im. N.I. Pirogova

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Predictors of tuberculosis infection among children and adolescents with positive results of a skin test with recombinant TB allergen

et al. 2021

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Introduction. In the context of a decrease in the tension of the epidemic situation on tuberculosis in Russia, it remains relevant to search for new ways to increase the effectiveness of preventive anti-tuberculosis measures among children and teenagers, taking into account an integrated approach to assessing all risk factors for tuberculosis in various age groups of the child population.Objective. Tо study the complex characteristics of groups at increased risk of tuberculosis among children of different ages who have positive results of a skin test with a recombinant tuberculous allergen (АТR).Materials and methods. The study retrospectively included 392 patients aged 2–17 years with a positive ATR test result. The рatients were randomized by age into 3 groups: in the 1st group there were 87 children 2–7 years old, in the 2nd group 182 children aged 8–14 years were included, in the 3rd group included 121 patients 15–17 years. The children did not have clinical and radiological signs of active tuberculosis and were HIV-negativ.Result. Among children and adolescents with a positive result of the test with ATR, social risk factors for developing tuberculosis (unfavorable living conditions, lack of permanent employment in 86.3% of parents) were determined. It was found that children living in families with low social status were dominated by contact with patients with multidrug resistance of the pathogen (MDR-TB), more than half of children (53.1%) had comorbidities. In 13.3% of children, small calcifications were detected in the lungs, in the intrathoracic lymph nodes.Conclusion. Among children 2–7 years old with positive results of the test with ATR, a complex of risk factors for the development of tuberculosis prevails: low material security in every second family, alcohol and drug dependence of parents in every third family, contact with MDR-TB patients in 56.5% of children, high incidence of concomitant pathology (in 67.4% of children).

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Immunodiagnostics of Tuberculosis: 10-Year Experience of Using Immunological Tests in Russia

Cited by 6 publications

References 24 publications

COVID-19 and Tuberculosis: Mathematical Modeling of Infection Spread Taking into Account Reduced Screening

COVID-19 and Tuberculosis: Mathematical Modeling of Infection Spread Taking into Account Reduced Screening

Abdominal tuberculosis in children

Predictors of tuberculosis infection among children and adolescents with positive results of a skin test with recombinant TB allergen

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