Immunodeficiency Syndromes and Gastrointestinal Disease

Ament, Marvin E.

doi:10.1016/s0031-3955(16)33209-6

Cited by 44 publications

(1 citation statement)

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“…While the majority of affected infants recover uneventfully, a certain proportion continue to have diarrhoea for protracted periods despite adequate supportive therapy (Avery et a/., 1968). Secondary sugar intolerance (Burke etal., 1965;Sutton and Hamilton, 1968), malnutrition (Lifshitz et a/., 1971), immunological deficiency disorders (Ament, 1975) and coeliac disease (Larcher etal., 1977) have been identified as some of the factors responsible for protracted diarrhoea in infancy. A group remains however in whom no cause for protracted diarrhoea can be found and the lack of definitive diagnosis has precluded a rational approach to therapy.…”

mentioning

confidence: 99%

Cow's Milk Protein Sensitive Enteropathy (CMPSE): An Important Cause of Protracted Diarrhoea in Infancy

Iyngkaran

Robinson

Davis

et al. 1979

J Paediatrics Child Health

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1979). Aust. Paediatr. J., 15, 266-270. Cow's milk protein sensitive enteropathy (CMPSE): an important cause of protracted diarrhoea in infancy.Twenty-six infants with protracted diarrhoea were studied, and 21 were found to have cow's milk protein sensitive enteropathy. Associated secondary sugar intolerance was present in the majority of these infants, but the symptoms did not improve with a lactose-free, cow's milk protein containing formula. Eleven infants tolerated and thrived well on a lactose and cow's milk protein-free formula. Ten infants required total parenteral nutrition for periods of 1 to 3 weeks before they tolerated a lactose and cow's milk protein-free formula orally. This limited study suggests that cow's milk protein sensitive enteropathy may be a major cause of protracted diarrhoea in infancy and that exclusion of cow's milk protein as well as lactose from the diet is essential in the nutritional rehabilitation of these infants. With careful manipulation of these special formulae the need for total parenteral nutrition may be obviated in many infants with protracted diarrhoea.

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