Immunodeficiencies Associated with Chronic Lymphocytic Leukemia and Non–Hodgkin’s Lymphomas

Gupta, Sudhir; Good, Robert A.

doi:10.1007/978-1-4613-4015-7_19

Cited by 7 publications

(3 citation statements)

References 73 publications

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“…Chronic lymphocytic leukemia (CLL) in 90% of cases represents a malignant expan sion of relatively immature B cells [53], A number of B cell and T cell defects have been reported in patients with B cell CLL [53], Kuntz [79] reported deficient AMLR in pa tients with CLL in the presence of AB serum. Smith et al [113] studied AMLR between T and non-T cells in medium-containing au tologous sera.…”

Section: Chronic Lymphocytic Leukemiamentioning

confidence: 99%

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Gupta¹

1983

Vox Sanguinis

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In this review are discussed the nature of T cell subsets, defined with monoclonal antibodies, responding in T-non-T and T-T autologous mixed-lymphocyte reactions (AMLR) and antigens stimulating in AMLR, soluble products of AMLR and generation of suppressor, helper and cytotoxic functions. On the basis of these data a model of immunoregulation in vivo can be proposed. We believe that AMLR is a real phenomenon and not an artefact and perhaps represents a mechanism by which various immune functions are regulated, including feedback regulation of AMLR. The significance of AMLR is further supported by studies in various human and animal diseases.

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Section: Chronic Lymphocytic Leukemiamentioning

confidence: 99%

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Gupta¹

1983

Vox Sanguinis

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“…Chronic lymphocytic leukemia (CLL) in 90% of cases represents a malignant expansion of relatively immature B cells [53]. A number of B cell and T cell defects have been reported in patients with B cell CLL [53]. Kuntz [79] reported deficient AMLR in patients with CLL in the presence ofAB serum.…”

Section: C'h Ron Ic L Y M P Hocyt Ic Leu K E M Iamentioning

confidence: 99%

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Gupta

1983

Vox Sanguinis

Self Cite

View full text Add to dashboard Cite

In this review are discussed the nature of T cell subsets, defined with monoclonal antibodies, responding in T-non-T and T-T autologous mixed-lymphocyte reactions (AMLR) and antigens stimulating in AMLR, soluble products of AMLR and generation of suppressor, helper and cytotoxic functions. On the basis of these data a model of immunoregulation in vivo can be proposed. We believe that AMLR is a real-phenomenon and not an artefact and perhaps represents a mechanism by which various immune functions are regulated, including feedback regulation of AMLR. The significance of AMLR is further supported by studies in various human and animal diseases.

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“…predominance of mature macrophages and active haemophagocytosis. Although investigations to exclude an opportunistic viral infection were incomplete in these patients, it is quite likely they had such an infection because of their immunodepressed state; CLL patients frequently have hypogammaglobulinaemia (Gupta & Good 1978), defective natural killer activity, defective antibody associated cytotoxicity (Gupta & Good 1980) and absent serum interferon (Ludwig 1979), and their immunosuppression is increased by previous cytotoxic therapy.…”

Section: Clinical Summary Of Cases With Hmr-like Syndrome Complicatinmentioning

confidence: 99%

Histiocytic Medullary Reticulosis Complicating Chronic Lymphocytic Leukaemia: Malignant or Reactive?

Manoharan

Catovsky

Lampert

et al. 1981

Scandinavian Journal of Haematology

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We describe 4 patients with a haemophagocytic syndrome resembling histiocytic medullary reticulosis (HMR) complicating chronic lymphocytic leukaemia (CLL) of 9 months to 8 years duration. Surface marker studies in 2 cases showed that the CLL lymphocytes were of B-cell type in one and of T-cell type in the other. 2 of the patients had histiological evidence of co-existing immunoblastic sarcoma at the time of diagnosis of the =-like syndrome and all 4 patients died within 3 weeks of this diagnosis. The pathogenesis of the HMR-like syndrome in these patients is discussed and it is concluded that it is probably reactive to an underlying opportunistic viral function related to their immunodepressed state secondary to CLL and/or the cytotoxic therapy.

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Immunodeficiencies Associated with Chronic Lymphocytic Leukemia and Non–Hodgkin’s Lymphomas

Cited by 7 publications

References 73 publications

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

Histiocytic Medullary Reticulosis Complicating Chronic Lymphocytic Leukaemia: Malignant or Reactive?

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