Immunocytochemical study of peyer's patches follicular-associated epithelium in the marsupial, Didelphis albiventris

Coutinho, H.B.; King, George; Sewell, Herb F.; Tighe, Patrick J.; Coutinho, V. B.; Robalinho, T. I.; Carvalho, Alexandre B. de

doi:10.1016/s0145-305x(05)80009-6

Cited by 29 publications

(25 citation statements)

References 21 publications

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“…The GALT were the last lymphoid tissue to fully mature histologically in the stripe-faced dunnart. This is consistent with other reports of metatherian development [Bryant and Shifrine, 1974;Ashman and Papadimitriou, 1975;Coutinho et al, 1994;Basden et al, Baker et al [1999] 1997; Baker et al, 1999;Cisternas and Armati, 1999] as well as in eutherians [Hinrichsen, 1997]. Table 3 summarises the development of the GALT in marsupial species studied to date.…”

Section: Discussionsupporting

confidence: 89%

Development of Lymphoid Tissues of the Stripe-Faced Dunnart (Sminthopsis macroura)

Old

Selwood

Deane

2003

Cells Tissues Organs

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The development of the lymphoid tissues of a model marsupial, the stripe-faced dunnart, has been described from birth to weaning, a period of 2.5 months. At birth the lymphoid tissues, including the thymus, lymph nodes and mucosa-associated lymphoid tissues, were undeveloped. A thoracic thymus consisting primarily of stromal tissue was observed by day 4 after birth but by day 12, lymphocytes were observed in the thymus and some cortico-medullary differentiation was apparent. Lymph nodes were histologically mature by day 31, the earliest day investigated for this tissue. In gut tissue, lymphoid follicles were first observed by day 57 post-partum. No bronchus-associated lymphoid tissue was observed in any lung samples. The thymus, lymph nodes and gut-associated lymphoid tissues were all distinguishable before weaning (day 70) but not all were histologically mature. The sequence of development of the lymphoid tissues in the stripe-faced dunnart was similar to those observed in other marsupial species.

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Section: Discussionsupporting

confidence: 89%

Development of Lymphoid Tissues of the Stripe-Faced Dunnart (Sminthopsis macroura)

Old

Selwood

Deane

2003

Cells Tissues Organs

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“…Both Yadav et al [1972b] and Basden et al [1997] failed to locate Peyer's patches in the quokka and tammar wallaby, respectively. However, Peyer's patches have been observed in Antechinus species [Poskitt et al, 1984a-c], the white-bellied opossum [Coutinho et al, 1993[Coutinho et al, , 1994, the koala and ringtail and brushtail possums and in the eastern grey kangaroo [Old and Deane, 2001]. In the koala, brushtail and ringtail possums Peyer's patches with distinct mantle zones, dome regions and caps were observed .…”

Section: Discussionmentioning

confidence: 99%

“…In the koala, brushtail and ringtail possums Peyer's patches with distinct mantle zones, dome regions and caps were observed . In contrast, the white-bellied opossum [Coutinho et al, 1993[Coutinho et al, , 1994 and Antechinus species [Poskitt et al, 1984a-c] Old/Selwood/Deane the white-bellied opossum [Coutinho et al, 1990]. It would appear that adult stripe-faced dunnart has the capacity to respond to antigen exposure to gut-derived antigens.…”

Section: Discussionmentioning

confidence: 99%

“…This has been documented, to varying degrees, in the American polyprotodont opossums, Monodelphis domestica [Stone et al, 1996], Didelphis virginiana [Block, 1964] and Didelphis albiventris [Coutinho et al, 1990] and a number of Australian diprotodonts and polyprotodonts including the common antechinus, Antechinus stuartii and Antechinus swainsonii [Poskitt et al, 1984a-c], the tammar wallaby, Macropus eugenii [Basden et al, 1996], the quokka, Setonix brachyurus [Yadav et al, 1972a, b], the brushtail possum, Trichosurus vulpecula and the koala, Phascolarctos cinereus . Most recently the availability of species cross-reactive antibodies to lymphocyte-associated antigens has permitted a more specific analysis of the lymphocyte populations in the lymphoid tissues of D. albiventris [Coutinho et al, 1994], the koala, the brushtail possum and the ringtail possum, Pseudocheirus peregrinus , the northern brown bandicoot, Isoodon macrourus [Cisternas and Armati, 1999] and the eastern grey kangaroo (Macropus giganteus) [Old and Deane, 2001].…”

Section: Introductionmentioning

confidence: 99%

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A Histological Investigation of the Lymphoid and Immunohaematopoietic Tissues of the Adult Stripe-Faced Dunnart (Sminthopsis macroura)

Old

Selwood

Deane

2003

Cells Tissues Organs

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This is the first published description of the lymphoid and immunohaematopoietic tissues of an Australian polyprotodont, the stripe-faced dunnart, Sminthopsis macroura and the first account of bronchus-associated lymphoid tissue (BALT) in a metatherian. Histologically, the tissue beds are similar in appearance to those reported in other adult eutherian and metatherian mammals. The liver and bone marrow were mature and virtually no haematopoietic activity was observed. The thymus had undergone involution but retained some lymphocytes. The spleen was similar to that observed in other metatherians containing areas of red and white pulp separated by a marginal zone. Lymph nodes, except for a pair in the posterior abdomen, were difficult to locate but were similar to those observed previously in other adult metatherians. Peyer’s patches were present; however, they lacked dome regions and sometimes had villi above them. BALT appeared to be both compartmentalised and non-compartmentalised in the adult stripe-faced dunnart.

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“…Here, we utilize such antibodies to label T and B cells of lymphoid tissues from healthy Tasmanian devils. In addition, an antibody against the alpha chain human HLA-DR, previously described to react against the homologous region of marsupial cells (Coutinho et al, 1994(Coutinho et al, , 1995, was used to identify MHC II positive cells in the tissues of healthy Tasmanian devils.…”

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confidence: 99%

A Histological and Immunohistochemical Analysis of Lymphoid Tissues of the Tasmanian Devil

Kreiss

Obendorf

Hemsley

et al. 2009

The Anatomical Record

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Tasmanian devil lymphoid tissues (thymus, spleen, and lymph node) from seven animals, including pouch young, juvenile, and adult devils, were investigated using histological and immunohistochemical techniques. Antibodies against the conserved intracytoplasmic portion of CD3 and CD79b (T-and B-cell markers, respectively) and MHC II were used to label immune cells. The thymus from the juvenile devils and the pouch young had CD3þ cells that were primarily located in the medulla of the organ. The spleen consisted of red and white pulp areas with characteristic lymphoid follicles with CD79bþ and MHC IIþ cells and nonfollicular T-cell-dominated periarteriolar lymphoid sheaths. Peripheral lymph nodes presented three distinct regions, outer cortex and medulla (both with primarily CD79bþ and MHC IIþ cells) and paracortex (mainly CD3þ cells). Tissue architecture and distribution of the immune cells were similar to that seen in eutherian mammals and other marsupials, indicating that the Tasmanian devil has all the structural elements necessary for effective adaptive immunity. Anat Rec, 292:611-620, 2009. V V C 2009 Wiley-Liss, Inc.

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Immunocytochemical study of peyer's patches follicular-associated epithelium in the marsupial, Didelphis albiventris

Cited by 29 publications

References 21 publications

Development of Lymphoid Tissues of the Stripe-Faced Dunnart <i>(Sminthopsis macroura)</i>

Development of Lymphoid Tissues of the Stripe-Faced Dunnart <i>(Sminthopsis macroura)</i>

A Histological Investigation of the Lymphoid and Immunohaematopoietic Tissues of the Adult Stripe-Faced Dunnart <i>(Sminthopsis macroura)</i>

A Histological and Immunohistochemical Analysis of Lymphoid Tissues of the Tasmanian Devil

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