Immunocytochemical study of cerebral perforating arteries in patients with cerebral infarctions.

Tagami, Motoki; Tsukada, Toyohiro; Kubota, Akiyoshi; Nara, Yasuo; Yamori, Yukio

doi:10.1267/ahc.26.109

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…At the advanced stage vascular damages occur at the inner layer of cerebral vessels which leads to vascular wall rupture that causes cerebral hemorrhage or to thrombosis inside the damaged blood vessels that causes cerebral infarction [15,16]. These pathological processes were further confirmed in human autopsy materials by an immuno-histochemical technique [17] in which macrophages were recruited to cause and heal cerebro-vascular damages. Vascular smooth muscle cells initially remained intact near the intima close to the vascular lumen as in SHRSP.…”

Section: Introductionmentioning

confidence: 99%

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

et al. 2010

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Taurine (T) was first noted as beneficial for stroke and cardiovascular diseases (CVD) prevention in genetic rat models, stroke-prone spontaneously hypertensive rats (SHRSP). The preventive mechanisms of T were ascribed to sympathetic modulation for reducing blood pressure (BP) and anti-inflammatory action. Recent epidemiological surveys revealed the involvement of inflammatory mediators in the pathogenesis of stroke and also atherosclerosis for which T was proven to be effective experimentally. Arterio-lipidosis prone rats, a substrain of SHRSP selectively bred for higher reactive hypercholesterolemia, quickly develop not only arterial fat deposition but also fatty liver which could be attenuated by dietary T supplementation. CARDIAC (CVD and Alimentary Comparison) Study was a WHO-coordinated multi-center epidemiological survey on diets and CVD risks and mortalities in 61 populations. Twenty-four-hour urinary (24U) T was inversely related significantly with coronary heart disease mortality. Higher 24U-T excreters had significantly lower body mass index, systolic and diastolic BP, total cholesterol (T-Cho), and atherogenic index (AI: T-Cho/high density lipoprotein-cholesterol) than lower T excreters. T effects on CVD risks were intensified in individuals whose 24U-T and -magnesium (M) excretions were higher. Furthermore, higher Na excreters with higher heart rate whose BP were significantly higher than those with lower heart rate were divided into two groups by the mean of 24U-T, high and low T excreters. Since the former showed significantly lower BP than the latter, T may beneficially affect salt-sensitive BP rise. Included among the typical 61 populations, were Guiyang, China or St. John’s, Newfoundland, Canada where in which the means of both 24U-T and -M were high or low, respectively. The former and the latter had low and high CVD risks, respectively. Australian Aboriginals living at the coastal area in Victoria were supposed to eat T- and M-rich bush and sea foods and be free from CVD 200 years ago, but they presently have nearly the highest CVD risks indicating that T- and/or M-containing seafood, vegetables, fruits, nuts, milk, etc, similar to prehistoric hunters’ and gatherers’ food should be good for CVD prevention. The preventive effects of T, good for health and longevity, first noted experimentally, were also proven epidemiologically in humans.

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Section: Introductionmentioning

confidence: 99%

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

et al. 2010

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Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

Yamori

Liu²,

Mori³

et al. 2009

Advances in Experimental Medicine and Biology

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The initial observation that taurine (T) prevented stroke in stroke-prone spontaneously hypertensive rats (SHRSP) led us to study the effects of T on cardiovascular diseases (CVD), as well as the epidemiological association of T and mortality rates, by using the data from WHO-coordinated Cardiovascular Disease and Alimentary Comparison Study, which covered 61 populations in 25 countries. In this study, 24 hour urine (24-U) samples were examined along with biomarkers of CVD risk. The mortality rate from ischemic heart disease (IHD), which was lowest among the Japanese compared to the populations of other developed countries, was positively related to total serum cholesterol (TC) and inversely related to 24-U taurine excretion (24-UT), as well as the n-3 fatty acid to total phospholipids ratio of the plasma membrane, both biomarkers of seafood intake. Analysis of 5 diet-related factors revealed that TC and BMI were positively associated with IHD mortality in both genders while Mg and T were negatively associated with IHD mortality. TC and sodium (Na) were negatively and positively associated with stroke mortality, respectively. 24-UT was negatively associated with stroke mortality. These five diet-related factors explained 61 and 49% of IHD and stroke variances in male, 63 and 36% of IHD and stroke variances in female, respectively.

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Nutritional Pathogenesis and Prevention of Stroke

Yamori¹,

Ikeda²,

Tagami³

et al. 2001

Nutrition and Brain

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Immunocytochemical study of cerebral perforating arteries in patients with cerebral infarctions.

Cited by 3 publications

References 18 publications

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

Taurine in health and diseases: consistent evidence from experimental and epidemiological studies

Taurine as the Nutritional Factor for the Longevity of the Japanese Revealed by a World-Wide Epidemiological Survey

Nutritional Pathogenesis and Prevention of Stroke

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