Immunocytochemical localization of the low-affinity nerve growth factor receptor (p75NGFR) in the cuneate nucleus of the rat and its relationship to cytochrome-oxidase activity

Crockett, David P.; Foschini, Darlene R.; Girgis, Wahid S.; Egger, Marcel

doi:10.1016/0006-8993(93)91256-r

Cited by 10 publications

(13 citation statements)

References 29 publications

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“…We demonstrated a close correspondence between p75‐immunoreactivity (IR) and the topographical and functional organization of the brainstem somatosensory nuclei in the rat (Crockett et al, 1993b, 1999; Foschini et al, 1994). Within the cuneate nucleus and the ventral portions of principal sensory nucleus of the trigeminal nerve, p75‐IR is distributed in a pattern that reflects the topography of the primary afferent innervation of the periphery: Dense clusters of p75‐positive terminals correspond to “patches” of cytochrome oxidase activity.…”

mentioning

confidence: 80%

“…In rodents, there is an apparent modularity in the organization of the somatosensory system. This is evidenced by “patchy” distributions of mitochondrial enzymes such as cytochrome oxidase (CO) or succinic dehydrogenase (SDH), replicating the topography of the peripheral innervation (Belford and Killackey, 1979, 1980; Crockett et al, 1993a,b, 1996a, 1999; Dawson and Killackey, 1987; Wall, 1988; Foschini et al, 1994; Killackey et al, 1994; Melzer et al, 1994). For example, the innervation of each whisker (mystacial vibrissa) is represented by a distinct patch of metabolic activity.…”

mentioning

confidence: 94%

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Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

2000

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confidence: 80%

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confidence: 94%

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

2000

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“…This area is known to contain the highest density of neurons projecting to the VB (Kemplay and Webster, 1989;Maslany et al, 1992;Crockett et al, 1993). Electron photomicrographs were taken for subsequent analysis of all the neuronal cell hodies in one section for each animal.…”

Section: Electron Microscopymentioning

confidence: 99%

“…This protocol allowed measurements of approximately four-fifths of the extent of the cuneate nucleus. I t is worth mentioning that the part of the nucleus analyzed is known to contain the region with the highest density of neurons projecting to the VB (Kemplay and Webster, 1989;Maslany et al, 1992;Crockett et. al., 1993).…”

Section: Quantitative Analysis In Nse-immunostained Sectionsmentioning

confidence: 99%

Effects of target deprivation on the morphology and survival of adult dorsal column nuclei neurons

Marty

Peschanski

1995

J of Comparative Neurology

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During development, interaction with target cells plays a critical role in the regulation of survival of afferent neurons. In an attempt to define the role of target cells in the adult central nervous system, the somatodendritic morphology and survival of adult cuneate neurons deprived of their targets by in situ injection of kainic acid in the rat thalamus were studied. In neuron-specific, enolase-immunostained sections, a 20% decrease in the mean longest diameter of the labeled cells was detected at 4 months postlesion. This somatic atrophy was accompanied by a loss of distal dendritic arborizations as observed after labeling by intracellular diffusion of horseradish peroxidase. Cytochrome oxidase staining did not reveal detectable alterations of the metabolic activity of these neurons, and an ultrastructural study also failed to demonstrate major changes in the neuronal somata. Cell counts indicated a much delayed death of 25% of the neurons at 10 months postlesion, whereas no neuronal death was detected at 7 months. The glial cells appeared unaltered both in number and in immunolabeling when using OX-42 antibodies or antiglial fibrillary acidic protein (anti-GFAP) antibodies. Results obtained in this time-course study indicate that neuronal death and alteration of the somatodendritic morphology are much delayed events after excitotoxic loss of targets. Somatodendritic atrophy occurs several months postlesion, and neuronal death occurs close to 1 year after lesion. These results suggest that the hypothesis of a necessary continuous trophic support by target cells does not hold as firmly for the adult central nervous system as during development.

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“…Some authors denied the presence of the DCN and medial lemniscus system in subreptilian vertebrates [6,7]. Others suggested that a primordial DCN are present in the obex region (the junction between the open medulla and closed medulla) of amphibians [8,9,10].…”

Section: First Appearance Of the Dcnmentioning

confidence: 99%

Functional and Anatomical Features of the Dorsal Column Nuclei in Mammals and Lower Animals

Zaqout

Al-Hussain²

2013

AJMBR

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The dorsal fasciculi of the spinal cord are known as the chief pathways for the conduction of impulses underlying deep sensibility and tactile discrimination from limbs which reach the thalamus and ultimately the cerebral cortex after a relay at a bulbar level, the dorsal column nuclei. It is believed that the development of the dorsal fasciculi and their nuclei in the mammalian and primate series is correlated with increasing sensory discrimination in the skin and the increased development of proprioceptive sense in the limb musculature. In this review we will discuss the reflection of the development of limbs and sensory discrimination in lower animals and mammals on the organization and some functional aspects of these nuclei.

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Immunocytochemical localization of the low-affinity nerve growth factor receptor (p75NGFR) in the cuneate nucleus of the rat and its relationship to cytochrome-oxidase activity

Cited by 10 publications

References 29 publications

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

Neurotrophin receptor (p75) in the trigeminal thalamus of the rat: Development, response to injury, transient vibrissa-related patterning, and retrograde transport

Effects of target deprivation on the morphology and survival of adult dorsal column nuclei neurons

Functional and Anatomical Features of the Dorsal Column Nuclei in Mammals and Lower Animals

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