Immunocytochemical localization of the AMPA glutamate receptor subtype GluR2/3 in the squid optic lobe

Kwon, Kyung-Min; Pak, Jae-Hong; Jeon, Chang‐Jin

doi:10.1016/j.acthis.2022.151941

Acta Histochemica

2022

DOI: 10.1016/j.acthis.2022.151941

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Immunocytochemical localization of the AMPA glutamate receptor subtype GluR2/3 in the squid optic lobe

Kyung-Min Kwon

Jae-Hong Pak

Chang‐Jin Jeon

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2023

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High-level RNA editing diversifies the coleoid cephalopod brain proteome

Voss,

Rosenthal

2023

Briefings in Functional Genomics

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Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid nervous system is also the only one currently known to recode the majority of expressed proteins through A-to-I RNA editing. The deamination of adenosine by adenosine deaminase acting on RNA (ADAR) enzymes produces inosine, which is interpreted as guanosine during translation. If this occurs in an open reading frame, which is the case for tens of thousands of editing sites in coleoids, it can recode the encoded protein. Here, we describe recent findings aimed at deciphering the mechanisms underlying high-level recoding and its adaptive potential. We describe the complement of ADAR enzymes in cephalopods, including a recently discovered novel domain in sqADAR1. We further summarize current evidence supporting an adaptive role of high-level RNA recoding in coleoids, and review recent studies showing that a large proportion of recoding sites is temperature-sensitive. Despite these new findings, the mechanisms governing the high level of RNA recoding in coleoid cephalopods remain poorly understood. Recent advances using genome editing in squid may provide useful tools to further study A-to-I RNA editing in these animals.

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High-level RNA editing diversifies the coleoid cephalopod brain proteome

Voss,

Rosenthal

2023

Briefings in Functional Genomics

View full text Add to dashboard Cite

show abstract

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Immunocytochemical localization of the AMPA glutamate receptor subtype GluR2/3 in the squid optic lobe

Cited by 1 publication

References 99 publications

High-level RNA editing diversifies the coleoid cephalopod brain proteome

High-level RNA editing diversifies the coleoid cephalopod brain proteome

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