Objective:The present study was undertaken to compare expression ofcyclin D1 in the epithelial part of odontogenickeratocysts, radicular cysts and ameloblastomas.
Material and Method:In this observational and cross-sectional study, immunohistochemical staining of cyclin D1 on formalinfixed, paraffin-embedded tissue sections of odontogenickeratocysts (n=14), radicular cysts (n=14) and amelobelastoma (n=14) was performed by standard EnVision method. Then, slides were studied to evaluate the following parameters in epithelial part of lesions: expression, expression pattern, staining intensity and localization of expression and clinicopathological parameters : gender, mean age and site of the lesion.
Results:The data analysis showed statistically significant difference in cyclin D1 expression in studied groups (p<0.05). Assessment of staining localization and staining pattern showed basal andparabasal localization and more cases of diffuse pat tern in odontogenickeratocysts, but difference was not statistically significant among groups respectively (p=0.393, 0.465). Considering staining intensity, cyclin D1 positive cells in odontogenickeratocysts showedmost cases of strong intensity, different from r adicular cysts and Amelobelastoma. The difference was statistically significant (p=0.002).Conclusion: these findings could support the theory about neoplastic origin of odontogenickeratocysts, but results may support that, these lesions are developmental cysts with neoplastic properties because of the high intrinsic growth potential.