Immunocytochemical detection of 1,25-dihydroxyvitamin D3 receptor in normal human tissues

Berger, U.; Wilson, P.; Colston, K. W.; Coombes, R. Charles; Pike, Jack W.; Haussler, Mark R.

doi:10.1016/8756-3282(87)90180-3

Cited by 27 publications

(35 citation statements)

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“…As shown in previous studies, we confirm that there is no correlation between the presence of VDR and ER/PR (Freake et al 1984;Ulmann et al 1984;Berger et al 1987). However, in contrast to other studies (Clark et al 1983;Mason et al 1983;Howat et al 1985), we were unable to demonstrate prognostic relevance for ER/PR expression, which might be due to the inclusion of the small number of patients.…”

Section: Discussioncontrasting

confidence: 52%

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer

Ditsch

Tóth

Mayr

et al. 2011

J Histochem Cytochem.

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SummaryIn this study, we analyzed vitamin D receptor (VDR) expression and survival in a breast cancer patient cohort of 82 breast cancer patients. Immunohistochemical analysis was possible in 91.5% of the patients (75/82). Staining was evaluated using the semi-quantitative assay according to Remmele and Stegner (immunoreactivity score [IRS]). IRS 0-1 was negative/very low, IRS 2-4 was moderate to high, and IRS 6-12 was high. Statistical analysis was performed by Spearman's correlation test (p<0.05 significant). Overall survival was analyzed using Kaplan-Meier estimations. Only 6 patients had a negative IRS. Moderate IRS values were present in 20 patients. Most of the patients had a high IRS (49). For survival analysis, data were dichotomized (IRS 0-4: negative to moderate and IRS 6-12: high VDR expression). In univariate analysis, VDR expression showed significant differences in progression-free survival (PFS) and overall survival (OS). Patients with high IRS scores showed significantly better PFS and OS than patients with moderate/negative IRS scores for VDR expression. Tumor size was significantly correlated to PFS. When analyzed separately, the three different IRS groups showed significant differences in VDR expression. The present data suggest that VDR expression in breast cancer tissue may be of clinical significance, and the results provide evidence that VDR may be a factor with prognostic relevance. (J Histochem Cytochem 60:121-129, 2012)

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Section: Discussioncontrasting

confidence: 52%

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer

Ditsch

Tóth

Mayr

et al. 2011

J Histochem Cytochem.

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“…A single study (40) demonstrated a role for vitamin D and its receptor in breast cancer in humans. As previous data have shown (41,42), an improved outcome was achieved in patients with high VDR-IRS than in patients with low IRS. Taken together, the current findings support the assumption that VDR is a factor with prognostic relevance in breast cancer.…”

Section: Discussionsupporting

confidence: 48%

Correlation of thyroid hormone, retinoid X, peroxisome proliferator-activated, vitamin D and oestrogen/progesterone receptors in breast carcinoma

et al. 2012

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Abstract. Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thyroid receptor (TR), retinoid X receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and vitamin D receptor (VDR) in malignant breast tumour tissue samples. Patients diagnosed and treated for breast cancer between 1990 and 2000 were included. Receptor expression was detected by immunohistochemical staining.

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“…Furthermore, increased RXR and VDR protein levels have been found in breast cancer tissues, compared with levels in normal breast tissues (Bortman et al, 2002;Friedrich et al, 2002). Several studies have demonstrated that a high proportion of breast cancer biopsy specimens contain vitamin D receptors (VDR) (Freake et al, 1984;Eisman et al, 1986;Berger et al, 1987). Moreover, an association between VDR levels and prognosis appears to exist; tumour receptor status has been positively related to disease-free survival (Colston et al, 1989;Berger et al, 1991).…”

Section: Boron Cross-talk With Calcitriolmentioning

confidence: 99%

Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy

Scorei¹

2011

Breast Cancer - Current and Alternative Therapeutic Modalities

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Immunocytochemical detection of 1,25-dihydroxyvitamin D3 receptor in normal human tissues

Cited by 27 publications

References 0 publications

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer

The Association between Vitamin D Receptor Expression and Prolonged Overall Survival in Breast Cancer

Correlation of thyroid hormone, retinoid X, peroxisome proliferator-activated, vitamin D and oestrogen/progesterone receptors in breast carcinoma

Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy

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