Immunocontraceptive properties of recombinant sperm protein DE: implications for the development of novel contraceptives

Immunization with Bin1b decreases sperm motility with compromised fertility in rats

“…Third, a large number of b-defensins have been found in the epididymis and implicated in the process of sperm maturation (17), and thus they may compensate for Bin1b during its immunization. Fourth, synthetic or recombinant peptide may have different immunogenic properties compared with the native proteins and may thus have reduced immunogenetic efficacy compared with the native ones (18). One possible way to improve the immunogenetic efficacy is to design tandem repeats peptide epitopes instead of a single one.…”

Immunogenicity Study of Plasmid DNA Encoding Mouse Cysteine‐Rich Secretory Protein‐1 (mCRISP1) as a Contraceptive Vaccine

“…Major increase in human population will take place in developing countries as compared to developed countries. 3 In addition, an ideal male contraceptive would allow normal hormone production and spermatogenesis in the testis but would prevent the post-testicular sperm maturation, thus blocking the ability of spermatozoa to fertilize the oocytes. 2 These information indicate the burning need for new contraceptive methods.…”

Effect of immunization against prostate- and testis-expressed (PATE) proteins on sperm function and fecundity in the rat

“…For example, immunization with the epididymal protein DE significantly affects fertility in both male and female rats (Ellerman et al, 2008). Similarly, cysteine-rich secretory protein 1 (CRISP1) immunization affected fertility in male and female mice (Munoz et al, 2012).…”